Research Outputs (49)

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Treatment horizons for triple-negative breast cancer
Yeo W. ( 2015 )
Hong Kong Journal of Radiology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.12809/hkjr1515321
Targeting Angiogenic Genes as a Therapeutic Approach for Hepatocellular Carcinoma
Wong CH, Wong CSC, Chan SL ( 2015 )
CURRENT GENE THERAPY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.2174/1566523214666141224094648
Targeting angiogenic genes as a therapeutic approach for hepatocellular carcinoma
Wong C.H., Wong C.S.C., Chan S.L. ( 2015 )
Current Gene Therapy
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.2174/1566523214666141224094648
Shear Wave Elastography - A New Quantitative Assessment of Post-Irradiation Neck Fibrosis
Liu K.H., Bhatia K., Chu W., He L.T., Leung S.F., Ahuja A.T. ( 2015 )
Ultraschall in der Medizin
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1055/s-0034-1366364
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial
Li J, Qin SK, Xu RH, Yau TCC, Ma B, Pan HM, Xu JM, Bai YX, Chi YHBL, Wang LW, Yeh KH, Bi F, Cheng Y, Le AT, Lin JK, Liu TS, Ma D, Kappeler C, Kalmus J, Kim TW ( 2015 )
LANCET ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1470-2045(15)70156-7
Receptor-type tyrosine-protein phosphatase kappa directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma
Chen YW, Guo TH, Shen LJ, Wong KY, Tao Q, Choi WWL, Au-Yeung RKH, Chan YP, Wong MLY, Tang JCO, Liu WP, Li GD, Shimizu N, Loong F, Tse E, Kwong YL, Srivastava G ( 2015 )
BLOOD
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1182/blood-2014-07-588970
Randomized phase II study of axitinib versus placebo plus best supportive care in second-line treatment of advanced hepatocellular carcinoma
Kang YK, Yau T, Park JW, Lim HY, Lee TY, Obi S, Chan SL, Qin SK, Kim RD, Casey M, Chen C, Bhattacharyya H, Williams JA, Valota O, Chakrabarti D, Kudo M ( 2015 )
ANNALS OF ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1093/annonc/mdv388
Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma
Chen T, Long BL, Ren GS, Xiang TX, Li LL, Wang ZH, He Y, Zeng Q, Hong SL, Hu GH ( 2015 )
JOURNAL OF CELLULAR BIOCHEMISTRY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1002/jcb.25135
Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection
Chan A.W.H., Chan S.L., Wong G.L.H., Wong V.W.S., Chong C.C.N., Lai P.B.S., Chan H.L.Y., To K.-F. ( 2015 )
Annals of Surgical Oncology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1245/s10434-015-4516-1
Prognostic Implication of Human Papillomavirus Types and Species in Cervical Cancer Patients Undergoing Primary Treatment
Lau YM, Cheung TH, Yeo WN, Mo F, Yu MY, Lee KM, Ho WCS, Yeung ACM, Law PTY, Chan PKS ( 2015 )
PLOS ONE
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1371/journal.pone.0122557
Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor
Yeung SF, Tong JHM, Law PPW, Chung LY, Lung RWM, Tong CYK, Chow C, Chan AWH, Wan IYP, Mok TSK, To KF ( 2015 )
JOURNAL OF THORACIC ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1097/JTO.0000000000000620
Preclinical evaluation of PI3K inhibitor BYL719 as a single agent and its synergism in combination with cisplatin or MEK inhibitor in nasopharyngeal carcinoma (NPC)
Wong CH, Ma BBY, Cheong HT, Hui CWC, Hui EP, Chan ATC ( 2015 )
AMERICAN JOURNAL OF CANCER RESEARCH
Publication in refereed journal
Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC)
Wong CH, Ma BBY, Hui CWC, Tao Q, Chan ATC ( 2015 )
AMERICAN JOURNAL OF CANCER RESEARCH
Publication in refereed journal
Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments
Sun K., Jiang P., Chan K.C.A., Wong J., Cheng Y.K.Y., Liang R.H.S., Chan W.-K., Ma E.S.K., Chan S.L., Cheng S.H., Chan R.W.Y., Tong Y.K., Ng S.S.M., Wong R.S.M., Hui D.S.C., Leung T.N., Leung T.Y., Lai P.B.S., Chiu R.W.K., Lo Y.M.D. ( 2015 )
Proceedings of the National Academy of Sciences of the United States of America
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1073/pnas.1508736112
Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response
Yeo W, Chan SL, Mo FKF, Chu CM, Hui JWY, Tong JHM, Chan AWH, Koh J, Hui EP, Loong H, Lee K, Li L, Ma B, To KF, Yu SCH ( 2015 )
BMC CANCER
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1186/s12885-015-1334-6
Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose
Venkatakrishnan K, Kim TM, Lin CC, Thye LS, Chng WJ, Ma B, Chen MH, Zhou XF, Liu H, Kelly V, Kim WS ( 2015 )
INVESTIGATIONAL NEW DRUGS
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1007/s10637-015-0258-y
Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer
Swain SM, Baselga J, Kim SB, Ro J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Heeson S, Clark E, Ross G, Benyunes MC, Cortes J ( 2015 )
NEW ENGLAND JOURNAL OF MEDICINE
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1056/NEJMoa1413513
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling
Li CH, Tang LP, Zhao LJ, Li LL, Xiao Q, Luo XR, Peng WY, Ren GS, Tao Q, Xiang TX ( 2015 )
AMERICAN JOURNAL OF CANCER RESEARCH
Publication in refereed journal
Novel therapeutic targets and predictive markers for hepatocellular carcinoma
Chan SL, Chan AWH, Yeo W ( 2015 )
EXPERT OPINION ON THERAPEUTIC TARGETS
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1517/14728222.2015.1031109
Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079)
Ma BBY, Goh BC, Lim WT, Hui EP, Tan EH, Lopes GD, Lo KW, Li L, Loong H, Foster NR, Erlichman C, King AD, Kam MKM, Leung SF, Chan KC, Chan ATC ( 2015 )
INVESTIGATIONAL NEW DRUGS
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1007/s10637-015-0264-0
Monotherapy Administration of Sorafenib in Patients With Non-Small Cell Lung Cancer (MISSION) Trial A Phase III, Multicenter, Placebo-Controlled Trial of Sorafenib in Patients with Relapsed or Refractory Predominantly Nonsquamous Non-Small-Cell Lung Cancer after 2 or 3 Previous Treatment Regimens
Paz-Ares L, Hirsh V, Zhang L, de Marinis F, Yang JCH, Wakelee HA, Seto T, Wu YL, Novello S, Juhasz E, Aren O, Sun Y, Schmelter T, Ong TJ, Pena C, Smit EF, Mok TS ( 2015 )
JOURNAL OF THORACIC ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1097/JTO.0000000000000693
Methylation of PLCD1 and adenovirus-mediated PLCD1 overexpression elicits a gene therapy effect on human breast cancer
Mu, Wang, Zhao, Li, Li, Chen, Luo, Qiu, Li, Ren, Xu, Zhou, Xiang ( 2015 )
Experimental cell research
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.yexcr.2015.01.017
Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
Lee AW, Ma BB, Ng WT, Chan AT ( 2015 )
Publication in refereed journal
View Full-text in CUHK:
JCO.2015.60.pdf
Digital Object Identifier (DOI): http://dx.doi.org/10.1200/JCO.2015.60.9347
Lymphoepithelioma-like hepatocellular carcinoma: An uncommon variant of hepatocellular carcinoma with favorable outcome
Chan A.W.H., Tong J.H.M., Pan Y., Chan S.L., Wong G.L.H., Wong V.W.S., Lai P.B.S., To K.-F. ( 2015 )
American Journal of Surgical Pathology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1097/PAS.0000000000000376
Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus
Huynh H, Hao HX, Chan SL, Chen D, Ong R, Soo KC, Pochanard P, Yang D, Ruddy D, Liu M, Derti A, Balak MN, Palmer MR, Wang Y, Lee BH, Sellami D, Zhu AX, Schlegel R, Huang A ( 2015 )
MOLECULAR CANCER THERAPEUTICS
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1158/1535-7163.MCT-14-0768
Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
Peiyong Jiang, Carol W. M. Chan, K. C. Allen Chan, Suk Hang Cheng, John Wong, Vincent Wai-Sun Wong, Grace L. H. Wong, Stephen L. Chan, Tony S. K. Mok, Henry L. Y. Chan, Paul B. S. Lai, Rossa W. K. Chiu, Y. M. Dennis Lo ( 2015 )
Proceedings of the National Academy of Sciences of the United States of America
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1073/pnas.1500076112
Intermediaries of branched chain amino acid metabolism induce fetal. hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells
Karkashon S, Raghupathy R, Bhatia H, Dutta A, Hess S, Higgs J, Tifft CJ, Little JA ( 2015 )
BLOOD CELLS MOLECULES AND DISEASES
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.bcmd.2015.05.006
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma
Zheng Y, Parsonage G, Zhuang XD, Machado LR, James CH, Salman A, Searle PF, Hui EP, Chan ATC, Lee SP ( 2015 )
CANCER IMMUNOLOGY RESEARCH
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1158/2326-6066.CIR-14-0203-T
Hong Kong Consensus Recommendations on the Management of Hepatocellular Carcinoma
POON Ronnie Tung-ping, CHEUNG Tom Tan-to, KWOK Philip Chong-hei, LEE Ann-shing, LI Tat-wing, LOKE Kwok-loon, CHAN Lam Stephen, CHEUNG Moon-tong, LAI Tak-wing, CHEUNG Chin-cheung, CHEUNG Foon-yiu, LOO Ching-kong, BUT Yiu-kuen, HSU Shing-jih, YU Chun Ho, YAU Thomas ( 2015 )
Liver Cancer
Publication in refereed journal
Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation- positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial
Soria JC, Wu YL, Nakagawa K, Kim SW, Yang JJ, Ahn MJ, Wang J, Yang JCH, Lu Y, Atagi S, Ponce S, Lee DH, Liu YP, Yoh K, Zhou JY, Shi XJ, Webster A, Jiang HY, Mok TSK ( 2015 )
LANCET ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1470-2045(15)00121-7
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1
Li MY, Liu Y, Liu LZ, Kong AWY, Zhao ZL, Wu B, Long X, Wu J, Ng CSH, Wan IYP, Du J, Mok TSK, Underwood MJ, Chen GG ( 2015 )
JOURNAL OF MOLECULAR MEDICINE-JMM
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1007/s00109-015-1300-4
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1
Li M.-Y., Liu Y., Liu L.-Z., Kong A.W.Y., Zhao Z., Wu B., Long X., Wu J., Ng C.S.H., Wan I.Y.P., Du J., Mok T.S.K., Underwood M.J., Chen G.G. ( 2015 )
Journal of Molecular Medicine
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1007/s00109-015-1300-4
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU
Li X, Yu J, Brock MV, Tao Q, Herman JG, Liang P, Guo MZ ( 2015 )
ONCOTARGET
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.18632/oncotarget.3413
Elucidating the prognostic significance of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer
Ma BB, Mo F, Tong JH, Wong A, Wong SCC, Ho WM, Wu C, Lam PWY, Chan KF, Chan TSK, Tsui WMS, Tsang AKH, Fung MNS, Chan ATC, To KF ( 2015 )
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1111/ajco.12342
DLEC1, a 3p tumor suppressor, represses NF-kappa B signaling and is methylated in prostate cancer
Zhang L, Zhang Q, Li LL, Wang ZH, Ying JM, Fan Y, He Q, Lv TJ, Han WK, Li J, Yang Y, Xu B, Wang L, Liu QL, Sun YH, Guo YL, Tao Q, Jin J ( 2015 )
JOURNAL OF MOLECULAR MEDICINE-JMM
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1007/s00109-015-1255-5
Crizotinib in the management of advanced-stage non-small-cell lung cancer
Loong HH, Mok K, Leung LKS, Mok TSK ( 2015 )
FUTURE ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.2217/FON.14.314
Comparative MiRNA expressional profiles and molecular networks in human small bowel tissues of necrotizing enterocolitis and spontaneous intestinal perforation
Ng P.C., Chan K.Y.Y., Leung K.T., Tam Y.H., Ma T.P.Y., Lam H.S., Cheung H.M., Lee K.H., To K.F., Li K., Neu J. ( 2015 )
PLoS ONE
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1371/journal.pone.0135737
Clinical Utility of Plasma Epstein-Barr Virus DNA and ERCC1 Single Nucleotide Polymorphism in Nasopharyngeal Carcinoma
Hui EP, Ma BBY, Chan KCA, Chan CML, Wong CSC, To KF, Chan AWH, Tung SY, Ng WT, Cheng AC, Lee VHF, Chan SL, Loong HHF, Kam MKM, Leung SF, Ho R, Mo F, Ngan RKC, Chan ATC ( 2015 )
CANCER
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1002/cncr.29413
Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: A combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6
Yang J.C.-H., Sequist L.V., Geater S.L., Tsai C.-M., Mok T.S.K., Schuler M., Yamamoto N., Yu C.-J., Ou S.H.I., Zhou C., Massey D., Zazulina V., Wu Y.-L. ( 2015 )
The Lancet Oncology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1470-2045(15)00026-1
Chemotherapy-Related Amenorrhea and Menopause in Young Chinese Breast Cancer Patients: Analysis on Incidence, Risk Factors and Serum Hormone Profiles
Liem GS, Mo FKF, Pang E, Suen JJS, Tang NLS, Lee KM, Yip CHW, Tam WH, Ng R, Koh J, Yip CCH, Kong GWS, Yeo W ( 2015 )
PLOS ONE
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1371/journal.pone.0140842
Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis
Blanchard P, Lee A, Marguet S, Leclercq J, Ng WT, Ma J, Chan ATC, Huang PY, Benhamou E, Zhu GP, Chua DTT, Chen Y, Mai HQ, Kwong DLW, Cheah SL, Moon J, Tung Y, Chi KH, Fountzilas G, Zhang L, Hui EP, Lu TX, Bourhis J, Pignon JP ( 2015 )
LANCET ONCOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1470-2045(15)70126-9
Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial
Mesía R, Henke M, Fortin A, Minn H, Yunes Ancona AC, Cmelak A, Markowitz AB, Hotte SJ, Singh S, Chan AT, Merlano MC, Skladowski K, Zhang A, Oliner KS, VanderWalde A, Giralt J ( 2015 )
Lancet Oncology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S1470-2045(14)71198-2
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes
Li L., Zhang Y., Fan Y., Sun K., Su X., Du Z., Tsao S.W., Loh T.K.S., Sun H., Chan A.T.C., Zeng Y.-X., Chan W.Y., Chan F.K.L., Tao Q. ( 2015 )
Epigenomics
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.2217/EPI.14.79
Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach-The ALBI Grade
Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W, Mo F, Lai P, Inarrairaegui M, Chan SL, Sangro B, Miksad R, Tada T, Kumada T, Toyoda H ( 2015 )
JOURNAL OF CLINICAL ONCOLOGY
Publication in refereed journal
View Full-text in CUHK:
jco.2014.57.9151.pdf
Digital Object Identifier (DOI): http://dx.doi.org/10.1200/JCO.2014.57.9151
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma
Feng FT, Cui Q, Liu WS, Guo YM, Feng QS, Chen LZ, Xu M, Luo B, Li DJ, Hu LF, Middeldorp JM, Ramayanti O, Tao Q, Cao SM, Jia WH, Bei JX, Zeng YX ( 2015 )
CHINESE JOURNAL OF CANCER
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1186/s40880-015-0073-z
Applicability of BALAD score in prognostication of hepatitis B-related hepatocellular carcinoma
Chan SL, Mo F, Johnson P, Li L, Tang N, Loong H, Chan AWH, Koh J, Chan ATC, Yeo W ( 2015 )
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1111/jgh.13005
Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13- S -hydroxyoctadecadienoic acid in non-small cell lung cancer
Li M.-Y., Yuan H.-L., Ko F.W.S., Wu B., Long X., Du J., Wu J., Ng C.S.H., Wan I.Y.P., Mok T.S.K., Hui D.S.C., Underwood M.J., Chen G.G. ( 2015 )
Cancer
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1002/cncr.29547
A nssessment of liver function in patients with hepatocellular carcinoma: A new evidence-based approach - The albi grade
Johnson P.J., Berhane S., Kagebayashi C., Satomura S., Teng M., Reeves H.L., O'Beirne J., Fox R., Skowronska A., Palmer D., Yeo W., Mo F., Lai P., Inarrairaegui M., Chan S.L., Sangro B., Miksad R., Tada T., Kumada T., Toyoda H. ( 2015 )
Journal of Clinical Oncology
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1200/JCO.2014.57.9151
Albumin-to-Alkaline Phosphatase Ratio: A Novel Prognostic Index for Hepatocellular Carcinoma
Chan AWH, Chan SL, Mo FKF, Wong GLH, Wong VWS, Cheung YS, Chan HLY, Yeo W, Lai PBS, To KF ( 2015 )
DISEASE MARKERS
Publication in refereed journal
Digital Object Identifier (DOI): http://dx.doi.org/10.1155/2015/564057

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Research Outputs (49)

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