研究成果 (77)

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Activation of the epithelial Na+ channel triggers prostaglandin E-2 release and production required for embryo implantation
Ruan YC, Guo JH, Liu XM, Zhang RJ, Tsang LL, Dong JD, Chen H, Yu MK, Jiang XH, Zhang XH, Fok KL, Chung YW, Huang HF, Zhou WL, Chan HC ( 2012 )
NATURE MEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1038/nm.2771
A defensin-like peptide from Phaseolus vulgaris cv. 'King Pole Bean'
Wong JH, Ip DCW, Ng TB, Chan YS, Fang F, Pan WL ( 2012 )
FOOD CHEMISTRY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.foodchem.2012.04.119
An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean
Chan YS, Wong JH, Fang EF, Pan WL, Ng TB ( 2012 )
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1093/abbs/gms003
Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells
Cheung FWK, Guo J, Ling YH, Che CT, Liu WK ( 2012 )
MARINE DRUGS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.3390/md10020465
A paradoxical teratogenic mechanism for retinoic acid
Lee LMY, Leung CY, Tang WWC, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS, Shum ASW ( 2012 )
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1073/pnas.1200872109
Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis
Fu WM, Zhang JF, Wang H, Tan HS, Wang WM, Chen SC, Zhu X, Chan TM, Tse CM, Leung KS, Lu G, Xu HX, Kung HF ( 2012 )
APOPTOSIS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1007/s10495-012-0729-y
A potential human hepatocellular carcinoma inhibitor from Bauhinia purpurea L. seeds: from purification to mechanism exploration
Fang EF, Bah CSF, Wong JH, Pan WL, Chan YS, Ye XJ, Ng TB ( 2012 )
ARCHIVES OF TOXICOLOGY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1007/s00204-011-0751-9
Cajaninstilbene Acid Relaxes Rat Renal Arteries: Roles of Ca2+ Antagonism and Protein Kinase C-Dependent Mechanism
Zhang DM, Li Y, Cheang WS, Lau CW, Lin SM, Zhang QL, Yao N, Wang Y, Wu X, Huang Y, Ye WC ( 2012 )
PLOS ONE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1371/journal.pone.0047030
CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development
Lu YC, Chen H, Fok KL, Tsang LL, Yu MK, Zhang XH, Chen J, Jiang XH, Chung YW, Ma ACH, Leung AYH, Huang HF, Chan HC ( 2012 )
CELL RESEARCH
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1038/cr.2012.88
CFTR negatively regulates cyclooxygenase-2-PGE2 positive feedback loop in inflammation
Chen J, Jiang XH, Chen H, Guo JH, Tsang LL, Yu MK, Xu WM, Chan HC ( 2012 )
JOURNAL OF CELLULAR PHYSIOLOGY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1002/jcp.23020
Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis
Ruan JQ, Li N, Xia QS, Fu PP, Peng SY, Ye Y, Lin G ( 2012 )
JOURNAL OF MASS SPECTROMETRY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1002/jms.2969
Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor
Xie H, Yung WH ( 2012 )
ACTA PHARMACOLOGICA SINICA
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1038/aps.2011.184
Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-kappa B in R-HepG2 Cell Line
Sun JG, Yeung CA, Co NN, Tsang TY, Yau E, Luo KW, Wu P, Wa JCY, Fung KP, Kwok TT, Liu FY ( 2012 )
PLOS ONE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1371/journal.pone.0040720
Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells
Liang J, Leung KK, Lam SY, Leung PS ( 2012 )
DIABETES OBESITY & METABOLISM
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1111/j.1463-1326.2012.01612.x
Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-B/COX-2/PGE(2)
Chen J, Fok KL, Chen H, Zhang XH, Xu WM, Chan HC ( 2012 )
HUMAN REPRODUCTION
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1093/humrep/des254
Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions
Zhou XL, Chan SW, Tseng HL, Deng Y, Hoi PM, Choi PS, Or PMY, Yang JM, Lam FFY, Lee SMY, Leung GPH, Kong SK, Ho HP, Kwan YW, Yeung JHK ( 2012 )
PHYTOMEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.phymed.2012.08.011
Design, synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo[3,2-b]-1, 2, 4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors
Xu HN, Jin Z, Liu SJ, Liu HM, Li S, Lin HQ, Wan DC, Hu C ( 2012 )
CHINESE CHEMICAL LETTERS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.cclet.2012.04.022
Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension Through a Glucagon-Like Peptide 1-Dependent Mechanism
Liu LM, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu YF, Zhu ZM, Xu AM, Lam KSL, Chen ZY, Ng CF, Yao XQ, Huang Y ( 2012 )
HYPERTENSION
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.195115
DL-3-n-Butylphthalide, an Anti-Oxidant Agent, Prevents Neurological Deficits and Cerebral Injury Following Stroke per Functional Analysis, Magnetic Resonance Imaging and Histological Assessment
Zhang LH, Yu WHA, Wang YXJ, Wang CM, Zhao F, Qi W, Chan WM, Huang Y, Wai MSM, Dong JH, Yew DT ( 2012 )
CURRENT NEUROVASCULAR RESEARCH
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.2174/156720212801618956
DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet
Chen JN, Jiang Y, Liang YT, Tian XY, Peng C, Ma KY, Liu J, Huang Y, Chen ZY ( 2012 )
ATHEROSCLEROSIS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.atherosclerosis.2012.01.005
Effects of Cigarette Smoke and its Active Components on Ulcer Formation and Healing in the Gastrointestinal Mucosa
Zhang L, Ren JW, Wong CCM, Wu WKK, Ren SX, Shen J, Chan RLY, Cho CH ( 2012 )
CURRENT MEDICINAL CHEMISTRY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.2174/092986712803413926
Effects of Combining Linagliptin Treatment with BI-38335, A Novel SGLT2 Inhibitor, on Pancreatic Islet Function and Inflammation in db/db Mice
Chen L, Klein T, Leung PS ( 2012 )
CURRENT MOLECULAR MEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.2174/156652412802480970
Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture
Du F, Fan M, Gong Q, Zhu LL, Zhu ZJ, Lu LN, Ke Y ( 2012 )
NEUROCHEMISTRY INTERNATIONAL
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.neuint.2012.01.008
Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)
Lei Y, Guo XG, Liu Y, Cao Y, Deng Y, Chen XF, Cheng CHK, Dawid IB, Chen YL, Zhao H ( 2012 )
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1073/pnas.1215421109
Electric cell-substrate impedance sensing as a screening tool for wound healing agents
Liu C.L., Tam J.C.W., Sanders A.J., Jiang D.G., Ko C.H., Fung K.P., Leung P.C., Harding K.G., Jiang W.G., Lau C.B.S. ( 2012 )
Cancer Metastasis - Biology and Treatment
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1007/978-94-007-4927-6_11
Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes
Feng R, Zhou XL, Or PMY, Ma JY, Tan XS, Fu J, Ma C, Shi JG, Che CT, Wang Y, Yeung JHK ( 2012 )
PHYTOMEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.phymed.2012.06.009
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways
Li L, Yue GGL, Lau CBS, Sun HD, Fung KP, Leung PC, Han QB, Leung PS ( 2012 )
TOXICOLOGY AND APPLIED PHARMACOLOGY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.taap.2012.04.021
Estrogen Controls embryonic stem cell proliferation via store-operated calcium entry and the nuclear factor of activated T-cells (NFAT)
Wong C.-K., So W.-Y., Law S.-K., Leung F.-P., Yau K.-L., Yao X., Huang Y., Li X., Tsang S.-Y. ( 2012 )
Journal of Cellular Physiology
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1002/jcp.22990
Flexible and Versatile as a Chameleon-Sophisticated Functions of microRNA-199a
Gu S, Chan WY ( 2012 )
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.3390/ijms13078449
Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma
Fu WM, Zhang JF, Wang H, Xi ZC, Wang WM, Zhuang P, Zhu X, Chen SC, Chang TM, Leung KS, Lu G, Xu HX, Kung HF ( 2012 )
JOURNAL OF PROTEOMICS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.jprot.2012.05.032
Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent
Wu XG, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y ( 2012 )
PLOS ONE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1371/journal.pone.0044622
Herb-drug interactions with Danshen (Salvia miltiorrhiza): A review on the role of cytochrome P450 enzymes
Zhou X., Chan K., Yeung J.H.K. ( 2012 )
Drug Metabolism and Drug Interactions
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1515/dmdi-2011-0038
Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer
Ren SX, Cheng ASL, To KF, Tong JHM, Li MS, Shen J, Wong CCM, Zhang L, Chan RLY, Wang XJ, Ng SSM, Chiu LCM, Marquez VE, Gallo RL, Chan FKL, Yu J, Sung JJY, Wu WKK, Cho CH ( 2012 )
CANCER RESEARCH
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1158/0008-5472.CAN-12-2359
Hypoxic preconditioning increases iron transport rate in astrocytes
Yang L, Fan M, Du F, Gong Q, Bi ZG, Zhu ZJ, Zhu LL, Ke Y ( 2012 )
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.bbadis.2011.12.004
iMOWSE, a scoring scheme bridging in silico and in vitro digestion in PMF
Leung RKK, Tsui SKW ( 2012 )
INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1504/IJDMB.2012.045543
Impact of Cell Type and Epitope Tagging on Heterologous Expression of G Protein-Coupled Receptor: A Systematic Study on Angiotensin Type II Receptor
Jiang LL, Teng GMK, Chan EYM, Au SWN, Wise H, Lee SST, Cheung WT ( 2012 )
PLOS ONE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1371/journal.pone.0047016
Impaired CFTR-Dependent Amplification of FSH-Stimulated Estrogen Production in Cystic Fibrosis and PCOS
Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang PB, Huang HF, Chan HC ( 2012 )
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1210/jc.2011-1363
Importance of Metabolic Activation Study to the Safe Use of Chinese Herbal Medicines
Ma B, Li N, Lin G ( 2012 )
CURRENT DRUG METABOLISM
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.2174/1389200211209050652
Inferring a protein interaction map of Mycobacterium tuberculosis based on sequences and interologs
Liu ZP, Wang JG, Qiu YQ, Leung RKK, Zhang XS, Tsui SKW, Chen LN ( 2012 )
BMC BIOINFORMATICS
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1186/1471-2105-13-S7-S6
Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes
Lau SLY, Yuen ML, Kou CYC, Au KW, Zhou JW, Tsui SKW ( 2012 )
JOURNAL OF CELLULAR BIOCHEMISTRY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1002/jcb.23412
In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells
Fang EF, Zhang CZY, Zhang L, Fong WP, Ng TB ( 2012 )
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.biocel.2012.04.013
Involvements of calcium channel and potassium channel in Danshen and Gegen decoction induced vasodilation in porcine coronary LAD artery
Hu F, Koon CM, Chan JYW, Lau KM, Kwan YW, Fung KP ( 2012 )
PHYTOMEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.phymed.2012.07.007
Ion channels/transporters as epigenetic regulators? -a microRNA perspective
Jiang XH, Zhang JT, Chan HC ( 2012 )
SCIENCE CHINA-LIFE SCIENCES
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1007/s11427-012-4369-9
Isolation of a Glucosamine Binding Leguminous Lectin with Mitogenic Activity towards Splenocytes and Anti-Proliferative Activity towards Tumor Cells
Chan YS, Wong JH, Fang EF, Pan WL, Ng TB ( 2012 )
PLOS ONE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1371/journal.pone.0038961
Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery
Deng Y, Ng ESK, Yeung JHK, Kwan YW, Lau CBS, Koon JCM, Zhou L, Zuo Z, Leung PC, Fung KP, Lam FFY ( 2012 )
JOURNAL OF ETHNOPHARMACOLOGY
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.jep.2011.11.021
Metabolic Conversion from Co-existing Ingredient Leading to Significant Systemic Exposure of Z-butylidenephthalide, a Minor Ingredient in Chuanxiong Rhizoma in Rat
Yan R, Ko NL, Ma B, Tam YK, Lin G ( 2012 )
CURRENT DRUG METABOLISM
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.2174/1389200211209050524
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes
Zhou XL, Wang Y, Or PMY, Wan DCC, Kwan YW, Yeung JHK ( 2012 )
PHYTOMEDICINE
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.phymed.2012.01.005
Momordica Charantia Lectin, a Type II Ribosome Inactivating Protein, Exhibits Antitumor Activity toward Human Nasopharyngeal Carcinoma Cells In Vitro and In Vivo
Fang EF, Zhang CZY, Ng TB, Wong JH, Pan WL, Ye XJ, Chan YS, Fong WP ( 2012 )
CANCER PREVENTION RESEARCH
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1158/1940-6207.CAPR-11-0203
NaHS relaxes rat cerebral artery in vitro via inhibition of L-type voltage-sensitive Ca2+ channel
Tian XY, Wong WT, Sayed N, Luo JL, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao XQ, Chen ZY, Huang Y ( 2012 )
PHARMACOLOGICAL RESEARCH
Publication in refereed journal
數位物件識別號 (DOI): http://dx.doi.org/10.1016/j.phrs.2011.11.006
Osteoporosis and Cigarette Smoking: The Association and Future
CHAN Lok Yi Ruby, ZHANG Li, LEUNG Ping Chung, CHO Chi Hin ( 2012 )
Adaptive Medicine
Publication in refereed journal

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研究成果 (77)

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