Is Danggui safe to be taken by breast cancer patients? - A skepticism finally answered by comprehensive preclinical evidence
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AbstractAngelica sinensis (AS, Danggui) has long been regarded to stimulate breast cancer growth; hence, the use of AS in breast cancer patients remains a major concern for both patients and practitioners. Since safety studies of herbs would be unethical to carry out in patients, the present study aimed to investigate the potential unsafe effects of AS in a systematic pre-clinical approach. Human breast cancer cells, breast orthotopic tumor-bearing mouse models, as well as primary breast cancer cells from patients’ tumors were used to evaluate the effect of AS hot water extract on the progression of breast tumors and/or growth of breast cancer cells. We showed that AS is not that stimulatory in breast cancer both in vitro and in vivo, though AS should still be used with caution in estrogen receptor-positive breast cancer patients. This novel approach of applying breast cancer cell lines, xenograft, and syngeneic tumors models, as well as primary breast cancer cells from patients’ tumors in Chinese medicines safety evaluation was proven feasible. Our finding is important information for patients, Chinese medicine practitioners, and clinicians on the safety use of AS in breast cancer, which will affect future clinical practice.
All Author(s) ListYue GGL, Wong LS, Leung HW, Gao S, Tsang JYS, Lin ZX, Law BKB, Tse GMK, Lau CBS
Journal nameFrontiers in Pharmacology
Year2019
Month6
Day25
Volume Number10
PublisherFRONTIERS MEDIA SA
Article number706
ISSN1663-9812
LanguagesEnglish-United Kingdom
Keywordsbreast cancer, Angelica sinensis, safety, estrogenic herbs, primary breast cancer cells, Chinese herbal medicines
Web of Science Subject CategoriesPharmacology & Pharmacy;Pharmacology & Pharmacy

Last updated on 2020-07-07 at 11:28