Using Drug Expression Profiles and Machine Learning Approach for Drug Repurposing.
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AbstractThe cost of new drug development has been increasing, and repurposing known medications for new indications serves as an important way to hasten drug discovery. One promising approach to drug repositioning is to take advantage of machine learning (ML) algorithms to learn patterns in biological data related to drugs and then link them up to the potential of treating specific diseases. Here we give an overview of the general principles and different types of ML algorithms, as well as common approaches to evaluating predictive performances, with reference to the application of ML algorithms to predict repurposing opportunities using drug expression data as features. We will highlight common issues and caveats when applying such models to repositioning. We also introduce resources of drug expression data and highlight recent studies employing such an approach to repositioning.
All Author(s) ListKai ZHAO, Hon-Cheong SO
Title of PublicationComputational Methods for Drug Repurposing
Detailed descriptionPart of the Methods in Molecular Biology book series (MIMB, volume 1903)
Volume Number1903
Pages219 - 237
LanguagesEnglish-United Kingdom

Last updated on 2021-02-12 at 00:39