Autophagy in intracellular bacterial infection
Publication in refereed journal

Times Cited
Altmetrics Information

Other information
AbstractAutophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic components for lysosomal degradation to maintain cellular homeostasis. Accumulating evidences showed that a specialized form of autophagy, known as xenophagy, could serve as an innate immune response to defend against pathogens invading inside the host cells. Correspondingly, infectious pathogens have developed a variety of strategies to disarm xenophagy, leading to a prolonged and persistent intracellular colonization. In this review, we first summarize the current knowledge about the general mechanisms of intracellular bacterial infections and xenophagy. We then focus on the ongoing battle between these two processes.
Acceptance Date30/07/2019
All Author(s) ListHu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Xiao ZG, Cho CH, Gin T, Chan MTV, Wu WKK, Zhang L
Journal nameSeminars in Cell and Developmental Biology
Volume Number101
Pages41 - 50
LanguagesEnglish-United Kingdom
KeywordsXenophagy, Intracellular bacteria, Infection

Last updated on 2021-17-09 at 00:10