Reducing length of stay with vitamin D: A systematic review
Refereed conference paper presented and published in conference proceedings


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AbstractBackground: Recent studies have also identified the role of vitamin D in the defence against infections. Association of vitamin D deficiency and sepsis is also well documented in the literature. Low vitamin D level is associated with poor clinical outcomes. This systematic review evaluates the effectiveness and validity of using vitamin D as treatment for sepsis or infection.
Methods: Our study reviewed all randomized controlled trials with patients of all ages with suspected or confirmed infection, sepsis or septic shock up until 2018. PRISMA guidelines were followed. Cochrane Central of Controlled trials, EMBASE, and OVID MEDLINE® are searched with the OVID interface. WHO International Clinical Trial Registry Platform, Web of Science, ClinicalTrials.gov were also searched.
Results: Literature search performed in July 2018 reviewed 669 studies. After duplicated studies were excluded, 650 titles and abstract were screened, 628 studies were excluded and 22 full-text were assessed. Four relevant studies were isolated, and only two studies had data on hospital length of stay, our primary outcome. We attempted to obtain additional data from authors of studies with no hospital LOS study with no avail. We considered these two studies to be high quality and low overall risk of bias.
Conclusion: Although the quality of the studies reviewed were good, the small number of the studies, small number of patients (a total of 184 patients) included and difference in patient cohort (age group, ethnicity, mortality rate, disease severity) made it impossible to draw any conclusions. This study highlights the need of a larger interventional study.
All Author(s) ListRonson S.L. LO, Ling Yan LEUNG, Yuk Ki LEUNG, Hersey Ho Sze WONG, Tak Kan WONG, Cherry C.Y. LAM, Krystal Xi Wing YAU, Mikkel BRABRAND, Colin A. GRAHAM
Name of ConferenceThe First Cochrane Hong Kong Symposium
Start Date of Conference23/05/2019
End Date of Conference24/05/2019
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Proceedings TitleThe First Cochrane Hong Kong Symposium
Year2019
Month5
Pages103 - 103
LanguagesEnglish-United Kingdom

Last updated on 2019-10-12 at 16:20