Facile difluoromethylation of aliphatic alcohols with an S-(difluoro-methyl)sulfonium salt: reaction, scope and mechanistic study
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摘要A facile and practical approach for the difluoromethylation of aliphatic alcohols with an S-(difluoromethyl)sulfonium salt was developed. A wide variety of alcohols with broad functional groups are compatible to furnish the corresponding alkyl difluoromethyl ethers in good to excellent yields under mild reaction conditions. Control experiments and DFT computational studies suggest that the difluoromethylation of alcohols mainly proceeds via a difluorocarbene pathway involving a five-membered transition state with the participation of water, whose crucial role in this reaction was also elucidated by control experiments.
出版社接受日期28.05.2019
著者G.-K. Liu, X. Li, W.-B. Qin, X.-S. Peng, H.N.C. Wong, L. Zhang, X. Zhang
期刊名稱Chemical Communications
出版年份2019
月份7
日期4
卷號55
期次52
出版社Royal Society of Chemistry
出版地United Kingdom
頁次7446 - 7449
國際標準期刊號1359-7345
語言英式英語
關鍵詞difluoromethylation, S-(difluoromethyl)sulfonium salt, aliphatic alcohol, mechanistic study

上次更新時間 2020-12-08 於 03:27