从出生队列研究中探讨影响儿童湿疹发生的易感因素 (Exploring risk factors for eczema development in Chinese infants: Lessons from a birth cohort)
Other conference paper


Full Text

Other information
AbstractBackground: Eczema is the commonest skin diseases in children, and it is important to identify predictors for eczema among asymptomatic babies so as to target appropriate preventive measures. Caucasian studies reported lower transepidermal water loss (TEWL) as an indicator of skin barrier dysfunction that preceded clinically evident eczema by 12 months.

Objective: This study investigated whether skin hydration (SH) of infants at one month and other possible demographic and early-life factors predict eczema development when subjects are 6 and 12 months of age.

Method: 120 Chinese newborns were recruited in this birth cohort study. Their SH was measured on left volar forearm (LVF), left antecubital fossa (LAF), and upper back (UPB) during 1-month home visits. Eczema was diagnosed by widely accepted criteria when subjects attended clinic visits at 6 and 12 months. Eczema severity was determined by SCORing Atopic Dermatitis (SCORAD) score. A validated Chinese questionnaire was used to collect information about confounders such as family history, mode of delivery, early-life diet, emollient use and second-hand smoking at baseline and follow-up visits.

Results: 75 of 120 babies have family history of allergies. Forty-six (48%) of 95 babies who attended 6-month visit had eczema, with 29 being rated by SCORAD to have moderate-to-severe eczema. At 12 months, fifty-one (61%) of 84 babies had eczema including 5 cases with moderate-to-severe disease. There was no significant association between SH at one month and eczema development by 6 and 12 months. Nonetheless, subjects’ SH measured at LAF at 1-month was significantly lower in those with moderate-to-severe eczema at 12 months (44.9±35.4) than those free from eczema (80.1±28.2) (p=0.045). In addition, emollient use at 1-month was associated with lower incidence of eczema ever by 12 months of age (52.7% vs 65.5%, 0.024).

Conclusion: We identify lower SH at 1-month to be predictive of moderate-to-severe in Chinese infants. Early-life emollient use, on the other hand, may protect these babies from developing infantile eczema. These results need to be replicated in larger birth cohort, while suggesting clinical benefits of early-life emollient in preventing eczema development
Acceptance Date01/03/2019
All Author(s) ListYehao CHEN, Wing Hung TAM, Paul Kay Sheung CHAN, Ting Fan LEUNG
Name of Conference中国研究型医院学会过敏医学专业委员会第二届过敏医学国际高峰论坛
Start Date of Conference12/04/2019
End Date of Conference13/04/2019
Place of ConferenceShanghai
Country/Region of ConferenceChina
Year2019
LanguagesChinese-Simplified
Keywordseczema, Chinese infants, skin hydration

Last updated on 2020-27-02 at 14:47