MRI volumetrics in parkinsonian syndromes
Refereed conference paper presented and published in conference proceedings


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摘要Objective: We aimed to explore the ability of MRI volumetrics by using an automated segmentation software called Accubrain in differentiating (1) between different parkinsonian syndromes and (2) between parkinsonian syndromes with normal controls.
Background: It is often challenging to differentiate idiopathic parkinson's disease (IPD) and atypical parkinsonism due to their similar clinical presentations especially during the early stage of disease, while their prognosis and treatment are different. Conventional MRI brain is insensitive in distinguishing various parkinsonian syndromes. Recent MRI post‐processing technological advancement allows automatic and rapid quantification of regional brain volumes, and can be potential tool to improve clinician's diagnostic accuracy of different parkinsonian syndromes.
Methods: Total of 36 subjects with various Parkinsonism syndromes(10 IPD, 18 multiple system atrophy [MSA], 8 progressive supranuclear palsy[PSP]) and 36 controls were recruited retrospectively (age 44 to 88years old).100% and 78% of the patients underwent MRI and FDG‐PET, respectively and all controls received MRI brain.The volume of the region of interests (ROI) in MRI brain was measured by an automatic software (Accubrain). Differences in volume of each ROI among IPD, MSA PSP and controls were analysed. Receiver operating characteristic curve analysis was used to evaluate the diagnostic ability by area under curve (AUC) and to select the cutoff value of individual ROI with the maximal sensitivity and specificity.
Results: In patients with IPD, the ratio of globus pallidus volume to total intracranial volume (ICV) was significantly larger than that of MSA and PSP groups (p‐value= 0.011, MSA
著者Ma K, Chan A, Shi L, Abrigo J, Cheung T, Lau C, Mok V
會議名稱2018 International Congress of Parkinson's Disease and Movement Disorders
會議開始日05.10.2018
會議完結日09.10.2018
會議地點Hong Kong
會議國家/地區香港
期刊名稱Movement Disorders
會議論文集題名Movement Disorders
系列標題Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
叢書冊次945
出版作品名稱MOVEMENT DISORDERS
出版年份2018
月份10
卷號33
期次Suppl 2
出版社Wiley
頁次S423 - S426
國際標準期刊號0885-3185
電子國際標準期刊號1531-8257
語言英式英語
關鍵詞Magnetic resonance imaging(MRI), Parkin, Parkinsonism
Web of Science 學科類別Clinical Neurology;Neurosciences & Neurology

上次更新時間 2021-19-09 於 00:47