Optimizing the Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) outcome in Parkinson's disease patient with interleaving stimulation
Refereed conference paper presented and published in conference proceedings


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摘要Objective: To explore interleaving versus conventional stimulation in subthlalmic nucleus (STN) deep brain stimulation (DBS) in optimizing the effect.

Background: STN DBS is effective for motor complication or symptoms in Parkinson's disease (PD). Due to the complex functional anatomy of the target, the effect of conventional stimulation (monopolar and bipolar stimulation) can be limited by simulation‐induced side effects, including dyskinesia and imbalance. We report a case with better effect comparing interleaving and conventional stimulation for optimizing the effect of STN DBS for PD.

Methods: A 59 ‐year old gentlemen with PD for 8 years suffered from motor –complication for 2 years. Before DBS, he had 40% “OFF” period in awake‐ time which affected his daily living i.e. driving, using computer and work. He received bilateral STN DBS in 2016. His” Off “symptoms could be reduced to 20% using monopolar stimulation at voltage 1.3, Pulse Width 60uS, Rate 130Hz. However, the stimulation caused right leg lateral swing during walking. When changed to bipolar setting to achieve the similar effect for his OFF symptoms, he developed hand clumsiness, which affected his computer work and driving. Finally, the left STN stimulation changed to switching between low voltage monopolar & high voltage bipolar interleaving stimulation. He enjoyed the same effect for his OFF symptoms without the side effects.

Conclusions: In selective case of STN DBS for PD, interleaving stimulation is useful for maximizing symptom control while minimizing side effects.
著者Lau C, Zhu C, Chan D, Ma K, Chan A, Yeung J, Mok V, Poon W
會議名稱2018 International Congress of Parkinson's Disease and Movement Disorders
會議開始日05.10.2018
會議完結日09.10.2019
會議地點Hong Kong
會議國家/地區香港
期刊名稱Movement Disorders
會議論文集題名Movement Disorders
系列標題Surgical Therapy: Parkinson's Disease
出版作品名稱MOVEMENT DISORDERS
出版年份2018
月份10
卷號33
期次Suppl 2
出版社Wiley
文章號碼513
頁次S237 - S238
國際標準期刊號0885-3185
電子國際標準期刊號1531-8257
語言英式英語
關鍵詞Deep brain stimulation (DBS)
Web of Science 學科類別Clinical Neurology;Neurosciences & Neurology

上次更新時間 2021-17-10 於 00:45