Pharmacological Basis and New Insights of Resveratrol Action in the Cardiovascular System
Publication in refereed journal


Times Cited
Altmetrics Information
.

Other information
AbstractResveratrol (trans-3, 4', 5-trihydroxystilbene) belongs to the family of natural phytoalexin. Resveratrol first raised our attention in 1992, due to the exhibited cardio-protective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angioregulatory effects against atherosclerosis, ischemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol-induced cardiovascular protection, and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti-aging agent against multiple aging-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.
All Author(s) ListChak Kwong CHENG, Jiang-Yun LUO, Chi Wai LAU, Zhen-Yu CHEN, Xiao Yu TIAN, Yu HUANG
Journal nameBritish Journal of Pharmacology
Detailed descriptionReview Article
Year2020
Month3
Volume Number177
Issue Number6
PublisherWiley
Pages1258 - 1277
ISSN0007-1188
eISSN1476-5381
LanguagesEnglish-United Kingdom

Last updated on 2021-23-11 at 00:14