Association between Fatigue and Cognition of Multiple Sclerosis in Hong Kong
Refereed conference paper presented and published in conference proceedings


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AbstractMultiple Sclerosis (MS) is one of the common neurological diseases characterized by chronic inflammatory demyelination in central nervous system. Cognitive impairment and fatigue are frequently reported in patients with demyelinated diseases. Currently, studies regarding Asian MS population were scarce.
This cross-sectional study aims to examine the cognitive profile, the correlation of fatigue level and cognition and explore the predictors on the global cognition of patients with MS.
30 participants diagnosed with demyelinating diseases were recruited. A collection of comprehensive cognitive test indices, The Hong Kong Version of Montreal Cognitive Assessment (HK-MoCA), Modified Fatigue Impact Scale (MFIS) and Kurtzke Expanded Disability Status Scale (EDSS) were used to evaluate the pattern of cognitive impairment, level of fatigue and physical disability respectively. The performance of each cognitive measures was compared with the normative data in Hong Kong.
The study revealed that half of them were cognitively impaired and 83% of them reported fatigue in MFIS. No statistical significant difference was found in cognitive tests between fatigue and non-fatigue MS. Only Trail making test (TMT) part B was moderately correlated with MFIS (r=-0.406, p< 0.05). Linear regression analysis revealed that EDSS was a significant predictor to HK-MoCA score (β=-1.192, p< 0.01).
In summary, the study outlined the cognitive profile of MS cohort in Hong Kong and drew the conclusions that fatigue is correlated with the mental processing speed but not the global cognition; and neurological disability is a moderate predictor to the cognitive performance in MS patients.
All Author(s) ListW. P. Suen, Adrian Wong, Frederick L. Y. Au, Cheryl C.K Au, Angel Ng, Alexander Lau
Name of Conference16th Asian Oceanian Congress of Neurology
Start Date of Conference08/11/2018
End Date of Conference11/11/2018
Place of ConferenceSeoul
Country/Region of ConferenceSouth Korea
Year2018
Month11
LanguagesEnglish-United Kingdom

Last updated on 2019-04-12 at 12:28