Predictors for Delayed Onset Dementia After Stroke or Transient Ischemic Attack – A 5-Year Follow-Up Study
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: We aimed to determine the association between baseline clinical and radiological factors and delayed onset dementia after stroke or transient ischemic attack (TIA).
Methods: We recruited consecutive subjects with stroke or TIA without early onset dementia. We conducted annual neuropsychological assessment for 5 years. We investigated the association between baseline demographic, clinical and radiological factors, as well as incident recurrent stroke with delayed onset dementia using Cox regression models.
Results: 1007 patients were recruited, of which 88 with early onset dementia and 162 who lost to all follow-up were excluded. 49 (6.5%) out of 757 patients have incident delayed onset dementia during the follow-up period. Using multi-variate cox regression, age (HR = 1.06, 95% CI 1.02 to 1.10,p=0.04), history of ischemic heart disease (HR = 2.64, 95% CI 1.23 to 5.66,p = 0.013), baseline waist circumference (HR = 1.03, 95% CI 1.00 to 1.06, p = 0.03) and the presence of ≥3 lacunes (HR = 3.04, 95% CI 1.60 to 5.77) were associated with delayed onset dementia after stroke. Rate of recurrent stroke was not different between patients with (4.1%) and without delay onset dementia (3.0%;p = 0.626)
Conclusion: Age, history of ischemic heart disease, baseline waist circumference and the presence of ≥3 lacunes are associated with delayed onset dementia after stroke/TIA
All Author(s) ListMoamina Ismail, Bonnie Y. K. Lam, Adrian Wong, Jill M. Abrigo, Winnie C. W. Chu, Alexander Y. L. Lau, Yannie O. Y. Soo, Thomas W. H. Leung, Vincent C. T. Mok
Name of ConferenceThe 9th International Conference of the International Society of Vascular Behavioral and Cognitive Disorders
Start Date of Conference14/11/2018
End Date of Conference17/11/2018
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Series TitleNeuroimaging and Other Biomarkers in VCI
Number in SeriesE-6
Year2018
Month11
Pages45 - 45
LanguagesEnglish-United Kingdom

Last updated on 2019-02-12 at 12:45