Brain volume loss can predict cognitive impairments by neuropsychological battery in a cross-sectional study of Chinese patients with multiple sclerosis
Refereed conference paper presented and published in conference proceedings


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摘要Background: Brain volume loss (BVL) has become an important biomarker for neurodegeneration in multiple sclerosis (MS). We investigated whether a fully automatic brain volume analysis can predict cognitive impairments by detailed neuropsychological tests.
Methods: We identified subjects from the prospective Chinese University of Hong Kong Multiple Sclerosis Registry who completed a standardized MRI brain and a 45-minute neuropsychological battery. Brain volume was calculated by the 3D T1 sequence by AccuBrain (www.brainnow.cn), a fully-automated brain segmentation measurement tool. Multiple cognitive impairments was defined as >=3 domain deficits in: verbal learning and memory, processing speed, selective attention, executive function, visual perception, simple auditory attention span, and auditory working memory. A cut-off of less than 5th percentile of brain parenchymal fraction (BPF) of published nomogram was used to define ‘significant’ BVL.
Results: Twenty-six MS subjects (22[85%] females, 23 relapsing MS, 2 clinically isolated syndrome, and 1 secondary progressive MS) were recruited. 18(69%) subjects had significant BVL. The mean age was 35.3+/-9.2 years and median EDSS was 2.75 (interquartile range: 1.00-3.50). Cognitive-impaired subjects (>=3 domains) had lower mean BPF (71.03 vs.72.91, p=0.005). BVL significantly correlated with impaired cognition (r=-0.658, p<0.001). BPF correlated with verbal learning and memory (r=0.421, p=0.032), processing speed (r=0.575, p=0.002), and selective attention (r=0.637, p<0.001). WMH correlated with verbal memory (r=-0.438, p=0.042) and visual perception (r=- 0.611, p=0.003). Hippocampal volume correlated with auditory attention (r=0.425, p=0.03) and auditory working memory (r=0.581, p=0.002).
Discussion: Worsening BVL measured by an automatic tool strongly correlated with multiple cognitive impairments among MS patients.
著者Ng A, Au C, Wong A, Abrigo J, Shi L, Chen QY, Mok V, Lau A
會議名稱11th Congress of the Pan-Asian-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (PACTRIMS)
會議開始日01.11.2018
會議完結日03.11.2018
會議地點Sydney
會議國家/地區澳大利亞
會議論文集題名MULTIPLE SCLEROSIS JOURNAL
系列標題Two Minute Oral Presentation of Selected Posters
出版作品名稱MULTIPLE SCLEROSIS JOURNAL
出版年份2019
月份3
卷號25
期次3
文章號碼O-16
頁次442 - 443
國際標準期刊號1352-4585
電子國際標準期刊號1477-0970
語言英式英語
Web of Science 學科類別Clinical Neurology;Neurosciences;Neurosciences & Neurology

上次更新時間 2021-10-01 於 02:24