A Tale of Three Gorges in the Yangtze River: Comparing the Prevalence of Metabolic Syndrome According to ATPIII, WHO, and IDF Criteria and the Association with Vascular Health in Modernizing China
Publication in refereed journal

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摘要Background: Metabolic syndrome (MS) is associated with atherosclerotic diseases. The prevalence of MS according to the Adult Treatment Panel III (ATPIII), World Health Organization (WHO), and International Diabetes Federation (IDF) criteria are variable but increasing in western countries and modernizing China. This study aimed to evaluate the prevalence of MS according to these three criteria, in farmers or ex-farming residents in three-gorges territories undergoing rapid lifestyle changes. Methods: We compared 95 residents (ex-farmers) in Wu Shan (WS) (28.4% men, aged 49.7 +/- 9 years) resettled uphill for 3-5 years, and 87 age- and gender-matched farmers in Da Chang (DC) (27.6% men, aged 48.8 +/- 10 years) before migration. MS and other traditional risk factors were assessed and carotid intima-media thickness (IMT) measured. Results: Ninety-nine percent of WS residents were retired or adopted nonfarming jobs. Compared with DC farmers, WS ex-farmers had higher waist circumference, low density lipoprotein-cholesterol, and triglycerides (P < 0.0001), but their blood pressures, HDL-cholesterol, and fasting glucose were similar. MS were identified in 43.2% (IDF), 36.8% (WHO), and 29.5% (ATPIII) respectively in WS ex-farmers, compared with 17.2%, 13.8%, and 11.5% respectively in DC farmers. Carotid IMT was significantly higher in WS ex-farmers (0.74 +/- 0.16 mm) than in DC farmers (0.64 +/- 0.11 mm) (P < 0.0001). On multivariate regression analysis, prevalence of MS was correlated with job nature (beta = 0.425, P < 0.0001). Carotid IMT was better correlated with IDF MS criteria (beta = 0.208, P = 0.021), independent of age and WS location (regression adjusted R-2 = 0.444, F-value 12.0, P < 0.0001), but not with the ATPIII or WHO criteria. Conclusions: IDF MS criteria is more sensitive, better correlates with atherosclerosis surrogate, and accordingly is more readily applicable to modernizing China.
出版社接受日期26.02.2019
著者Woo KS, Hu YJ, Chook P, Wei AN, Chan R, Yin YH, Celermajer DS
期刊名稱Metabolic Syndrome and Related Disorders
出版年份2019
月份4
卷號17
期次3
出版社MARY ANN LIEBERT, INC
頁次137 - 142
國際標準期刊號1540-4196
電子國際標準期刊號1557-8518
語言英式英語
關鍵詞ATPIII, WHO and IDF criteria, metabolic syndrome, cardiometabolic health, three-gorges dam territories
Web of Science 學科類別Medicine, Research & Experimental;Research & Experimental Medicine

上次更新時間 2021-13-10 於 23:44