NAFLD Related-HCC: The Relationship with Metabolic Disorders
Chapter in an edited book (author)


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AbstractObesity increases death rates of all cancers including non-alcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (NAFLD-HCC). NAFLD is considered as hepatic manifestation of metabolic syndrome and is a multi-system disease. Recent prevalence studies have intensively reported the association of obesity, metabolic risk factors and HCC incidence and mortality. Mechanistic studies suggested that immune response, PI3K/AKT/mTOR/PTEN pathway, mitochondrial dysfunction and genetic alterations are important mediators in the progression of NAFLD-HCC from metabolic disorder. In this book chapter, we attempt to collate current research on NAFLD-HCC that lead to our understandings on how metabolic disorders may intersect with cancer development. We also discussed the prevention options of NAFLD-HCC in view of obesity and metabolic disorder. These studies have extended our knowledge on the complicated mechanism of NAFLD and HCC, and provided the prevention options of NAFLD-HCC in patients with obesity and metabolic diseases.
Acceptance Date28/06/2018
All Author(s) ListXiang Zhang
All Editor(s) ListJun Yu
Book titleObesity, Fatty Liver and Liver Cancer
Year2018
PublisherSpringer Singapore
Pages55 - 62
ISBN978-981-10-8683-0
eISBN978-981-10-8684-7
LanguagesEnglish-United Kingdom

Last updated on 2020-12-07 at 03:30