Current status of familial hypercholesterolemia in Chinese populations
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose of review

Heterozygous familial hypercholesterolemia often went unrecognized in China when population cholesterol levels were low, but rapid economic development has changed the situation. This review will discuss the current position of awareness, diagnosis, and management of familial hypercholesterolemia in Chinese populations.

Recent findings

The phenotype of familial hypercholesterolemia in China and other Chinese populations has become similar to that in Western countries, although it may still be somewhat less severe. The prevalence in Chinese populations is also similar to that in other countries and it has been found in up to 7% of Chinese patients with premature coronary heart disease. Most of the mutations are in the low-density lipoprotein receptor gene but the pattern of mutations differs from that in Whites. Chinese patients may be more responsive to statins than Whites but patients with familial hypercholesterolemia are often undertreated.

Summary

Increasing population cholesterol levels have changed the phenotype of familial hypercholesterolemia in China and Chinese patients now resemble those in Western countries. International initiatives are facilitating increased awareness and identification of cases and more effective management of the condition.
著者Tomlinson B, Hu M, Chow E
期刊名稱Current Opinion in Lipidology
出版年份2019
月份4
卷號30
期次2
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次94 - 100
國際標準期刊號0957-9672
電子國際標準期刊號1473-6535
語言英式英語
關鍵詞Chinese, coronary heart disease, familial hypercholesterolemia, phenotype, statin
Web of Science 學科類別Biochemistry & Molecular Biology;Endocrinology & Metabolism;Peripheral Vascular Disease;Biochemistry & Molecular Biology;Endocrinology & Metabolism;Cardiovascular System & Cardiology

上次更新時間 2020-02-08 於 03:05