Current status of familial hypercholesterolemia in Chinese populations
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AbstractPurpose of review

Heterozygous familial hypercholesterolemia often went unrecognized in China when population cholesterol levels were low, but rapid economic development has changed the situation. This review will discuss the current position of awareness, diagnosis, and management of familial hypercholesterolemia in Chinese populations.

Recent findings

The phenotype of familial hypercholesterolemia in China and other Chinese populations has become similar to that in Western countries, although it may still be somewhat less severe. The prevalence in Chinese populations is also similar to that in other countries and it has been found in up to 7% of Chinese patients with premature coronary heart disease. Most of the mutations are in the low-density lipoprotein receptor gene but the pattern of mutations differs from that in Whites. Chinese patients may be more responsive to statins than Whites but patients with familial hypercholesterolemia are often undertreated.


Increasing population cholesterol levels have changed the phenotype of familial hypercholesterolemia in China and Chinese patients now resemble those in Western countries. International initiatives are facilitating increased awareness and identification of cases and more effective management of the condition.
All Author(s) ListTomlinson B, Hu M, Chow E
Journal nameCurrent Opinion in Lipidology
Volume Number30
Issue Number2
Pages94 - 100
LanguagesEnglish-United Kingdom
KeywordsChinese, coronary heart disease, familial hypercholesterolemia, phenotype, statin
Web of Science Subject CategoriesBiochemistry & Molecular Biology;Endocrinology & Metabolism;Peripheral Vascular Disease;Biochemistry & Molecular Biology;Endocrinology & Metabolism;Cardiovascular System & Cardiology

Last updated on 2021-13-06 at 01:16