Genomics and metagenomics of colorectal cancer
Publication in refereed journal


Times Cited
Web of Science0WOS source URL (as at 30/06/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractColorectal cancer (CRC) is a common cancer globally. It is a complex disease influenced by genetic and environmental factors. Early studies on familial cases have identified major genes involved in CRC, such as proto-oncogenes KRAS, PIK3CA and BRAF, and tumour-suppressor genes APC and TP53. These genes have provided valuable insight into the molecular pathogenesis of CRC, and some have made ways to clinical utility to help diagnose cancer syndromes, prognosticate oncological outcomes and predict treatment responses. While these genetic factors are important, recent studies have suggested contribution of microorganisms to colorectal carcinogenesis. Observational studies, animal experiments and translational works have identified several microorganisms as potential carcinogenic bacteria, such as Fusobacterium nucleatum and Peptostreptococcus anaerobius. With the advent of sequencing technology and bioinformatics, more genomic and metagenomic factors are being uncovered as important players in CRC carcinogenesis. This article aims to review recent genomic and metagenomic discoveries relating to CRC.
All Author(s) ListCharmaine Ng, Haojun Li, William K. K. Wu, Sunny H. Wong, Jun Yu
Journal nameJournal of Gastrointestinal Oncology
Year2019
Month12
Volume Number10
Issue Number6
Pages1164 - 1170
ISSN2078-6891
eISSN2219-679X
LanguagesEnglish-United States

Last updated on 2020-01-07 at 04:49