tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression
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AbstracttRNA-derived stress-induced RNAs (tiRNAs), important components of tRNA-derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
Acceptance Date14/06/2019
All Author(s) ListEn‐Wei Tao, Wing Yin Cheng, Wei‐Lin Li, Jun Yu, Qin‐Yan Gao
Journal nameJournal of Cellular Physiology
Year2020
Month2
Day1
Volume Number235
Issue Number2
PublisherWiley: 12 months
Pages683 - 690
ISSN0021-9541
LanguagesEnglish-United States

Last updated on 2020-02-04 at 01:05