New insights and therapeutic implication of gut microbiota in non-alcoholic fatty liver disease and its associated liver cancer
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AbstractThe gastrointestinal tract represents one of the largest interfaces between the host and environmental factors. It contains a vast and complex community of microbes, forming what is collectively known as the microbiota. This gut microbiota plays a pivotal role in the maintenance of health, and 'dysbiosis' of the gut microbiota, commonly considered as perturbation of microbiota diversity and composition, has been associated with intestinal and extra-intestinal diseases, including non-alcoholic fatty liver disease (NAFLD) and its associated hepatocellular carcinoma (NAFLD-HCC).

In this review, we highlight microbiota dysbiosis and the microbiota-host interactions that link to the pathogenesis of NAFLD and NAFLD-HCC. We discuss the potential therapeutic implications of the gut microbiota in the progression of NAFLD-HCC.
All Author(s) ListNiama Ezzaidi, Xiang Zhang, Olabisi Oluwabukola Coker, Jun Yu
Journal nameCancer Letters
Year2019
Month9
Day10
Volume Number459
Pages186 - 191
ISSN0304-3835
LanguagesEnglish-United States

Last updated on 2020-06-07 at 02:12