Retina Genes in Chinese
Chapter in an edited book (author)


摘要Retina is a multilayered structure containing several different cell types crucial for visual functions. Light signals are converted into electrochemical signals on the retina and transferred to the brain through the optic nerve. A dysfunctional retina leads to various retinal diseases that can result in vision impairment and even irreversible blindness. Genetic factors play important roles in retina structure and functions. In recent decades, there are significant advancements in mapping retina genes associated with retinal diseases, some are monogenic and some multifactorial in etiology. Some retinal diseases overlap in clinical courses and even genetic constitutions, with both similarities and differences in presentations among ethnic populations. We have investigated CFH, HTRA1, BEST1, CETP, ABCA4, RHO, RP1, CYP4V2, and other genes in Chinese patients with retinal diseases including age-related macular degeneration, polypoidal choroidal vasculopathy diabetic retinopathy, retinitis pigmentosa, Best vitelliform macular dystrophy, and Stargardt disease.
著者He J., Chu W. K., Ma L., Pang C. C. P., Chen G. L. J
編輯Prakash Gyan, Iwata Takeshi
書名Advances in Vision Research, Volume II: Genetic Eye Research in Asia and the Pacific
系列標題Essentials in Ophthalmology
出版地Berlin, Germany
頁次177 - 190

上次更新時間 2022-13-01 於 00:54