Retina Genes in Chinese
Chapter in an edited book (author)


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AbstractRetina is a multilayered structure containing several different cell types crucial for visual functions. Light signals are converted into electrochemical signals on the retina and transferred to the brain through the optic nerve. A dysfunctional retina leads to various retinal diseases that can result in vision impairment and even irreversible blindness. Genetic factors play important roles in retina structure and functions. In recent decades, there are significant advancements in mapping retina genes associated with retinal diseases, some are monogenic and some multifactorial in etiology. Some retinal diseases overlap in clinical courses and even genetic constitutions, with both similarities and differences in presentations among ethnic populations. We have investigated CFH, HTRA1, BEST1, CETP, ABCA4, RHO, RP1, CYP4V2, and other genes in Chinese patients with retinal diseases including age-related macular degeneration, polypoidal choroidal vasculopathy diabetic retinopathy, retinitis pigmentosa, Best vitelliform macular dystrophy, and Stargardt disease.
All Author(s) ListHe J., Chu W. K., Ma L., Pang C. C. P., Chen G. L. J
All Editor(s) ListPrakash Gyan, Iwata Takeshi
Book titleAdvances in Vision Research, Volume II: Genetic Eye Research in Asia and the Pacific
Series TitleEssentials in Ophthalmology
Year2018
PublisherSpringer
Place of PublicationBerlin, Germany
Pages177 - 190
ISBN978-981-13-0883-3
eISBN978-981-13-0884-0
LanguagesEnglish-United Kingdom

Last updated on 2021-26-11 at 00:00