Hypofractionated Radiosurgery for Large Cerebral Arteriovenous Malformation: A Case Series and Follow Up Results
Refereed conference paper presented and published in conference proceedings

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AbstractBackground and Aims:
Treatment of large cerebral arteriovenous malformation (AVM) is of increased risk and can be challenging. Radiosurgery is commonly employed for treatment of AVM that are deep seated or located in eloquent area. However, efficacy of single dose RS is limited by AVM size. We have previously adopted a hypofractionated RS for large AVM radiosurgery and we aimed to assess their efficacy as compared to single dose radiosurgery in our institute.

Method:
We retrospectively reviewed the radiosurgery record in an university-affiliated regional neurosurgical referral centre in Hong Kong from January 1998 to September 2017. We retrieved patient records of AVM undergoing RS with imaging and clinical follow up assessments at 4 or more years afterwards.

Results:
Thirty-five patients were recruited into the current study. Age was 32+/-14 years and 18(51%) were male. Thirteen (37%) presented with hemorrhage related to AVM and 17(49%) had prior AVM treatment. The AVM volume was 25+/-21cm3. AVM obliteration without new or increased deficit was achieved in 18(51%). Thirteen (37%) underwent hypofractionated RS and 22 (63%) underwent single dose RS. The AVM volume was higher in hypofractionated RS (37+/-30cm3 versus 18+/-7cm3, p=0.045). There was a trend towards higher AVM obliteration without new or increased deficit in hypofractionated RS (62% versus 41%, OR 2.3 95%CI: 0.6–3.4, p=0.238).

Conclusion:
In selective large AVM patients, hypofractionated RS resulted in higher AVM obliteration without new or increased deficit as compared to single dose RS.
Acceptance Date16/05/2018
All Author(s) ListGeorge Kwok Chu WONG, K. Michael
Name of Conference4th European Stroke Organisation Conference
Start Date of Conference16/05/2018
End Date of Conference18/05/2018
Place of ConferenceGothenburg
Country/Region of ConferenceSweden
Proceedings TitleEuropean Stroke Journal
Year2018
Month5
Day16
Volume Number3
Issue NumberSuppl 1
PublisherSAGE Journal
Pages495 - 495
ISSN2396-9873
eISSN2396-9881
LanguagesEnglish-United Kingdom
KeywordsHypofractionated radiosurgery, cerebral arteriovenous malformation

Last updated on 2020-18-11 at 00:52