Chiral Hydroxytetraphenylene-Catalyzed Asymmetric Conjugate Addition of Boronic Acids to Enones
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Abstract(S)-2,15-Br-2-DHTP-catalyzed asymmetric conjugate addition of boronic acids to beta-trifluoromethyl alpha,beta-unsaturated ketones and enones was studied. The reaction afforded the corresponding Michael addition products in moderate to high yields with excellent enantioselectivities (up to 99:1 er). This catalytic system features mild reaction conditions, high efficiency, and tolerance to heteroarylboronic acids.
Acceptance Date08/05/2019
All Author(s) ListG.-L. Chai, A-Q. Sun, D. Zhai, J. Wang, W.-Q. Deng, H.N.C. Wong, J. Chang
Journal nameOrganic Letters
Year2019
Month7
Day5
Volume Number21
Issue Number13
PublisherAmerican Chemical Society
Place of PublicationColumbus, Ohio
Pages5040 - 5045
ISSN1523-7060
eISSN1523-7052
LanguagesEnglish-United States
Keywordshydroxytetraphenylene, asymmetric conjugate addition, boronic acid.

Last updated on 2020-02-07 at 03:24