Advances in multidisciplinary therapy for meningiomas
Publication in refereed journal


摘要Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.
著者Brastianos PK, Galanis E, Butowski N, Chan JW, Dunn IF, Goldbrunner R, Herold-Mende C, Ippen FM, Mawrin C, McDermott MW, Sloan A, Snyder J, Tabatabai G, Tatagiba M, Tonn JC, Wen PY, Aldape K, Nassiri F, Zadeh G, Jenkinson MD, Raleigh DR, Aldape K, Aldape K, Au K, Barnhartz-Sloan J, Bi WL, Brastianos PK, Butowski N, Carlotti C, Cusimano MD, DiMeco F, Drummond K, Dunn IF, Galanis E, Giannini C, Goldbrunner R, Griffith B, Hashizume R, Hanemann CO, Herold-Mende C, Horbinski C, Huang RY, James D, Jenkinson MD, Jungk C, Kaufman TJ, Krischek B, Lachance D, Lafougere C, Lee I, Liu JC, Mamatjan Y, Mansouri A, Mawrin C, McDermott M, Munoz D, Nassiri F, Noushmehr H, Ng HK, Perry A, Pirouzmand F, Poisson LM, Pollo B, Raleigh D, Sahm F, Saladino A, Santarius T, Schichor C, Schultz D, Schmidt NO, Selman W, Sloan A, Spears J, Snyder J, Suppiah S, Tabatabai G, Tatagiba M, Tirapelli D, Tonn JC, Tsang D, Vogelbaum MA, von Deimling A, Wen PY, Walbert T, Westphal M, Workewych AM, Zadeh G
出版社Oxford University Press (OUP): Policy B - Oxford Open Option F
頁次i18 - i31
關鍵詞clinical trial, meningioma, radiation, surgery, targeted therapy
Web of Science 學科類別Oncology;Clinical Neurology;Oncology;Neurosciences & Neurology

上次更新時間 2020-28-05 於 02:19