Advances in multidisciplinary therapy for meningiomas
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AbstractSurgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.
All Author(s) ListBrastianos PK, Galanis E, Butowski N, Chan JW, Dunn IF, Goldbrunner R, Herold-Mende C, Ippen FM, Mawrin C, McDermott MW, Sloan A, Snyder J, Tabatabai G, Tatagiba M, Tonn JC, Wen PY, Aldape K, Nassiri F, Zadeh G, Jenkinson MD, Raleigh DR, Aldape K, Aldape K, Au K, Barnhartz-Sloan J, Bi WL, Brastianos PK, Butowski N, Carlotti C, Cusimano MD, DiMeco F, Drummond K, Dunn IF, Galanis E, Giannini C, Goldbrunner R, Griffith B, Hashizume R, Hanemann CO, Herold-Mende C, Horbinski C, Huang RY, James D, Jenkinson MD, Jungk C, Kaufman TJ, Krischek B, Lachance D, Lafougere C, Lee I, Liu JC, Mamatjan Y, Mansouri A, Mawrin C, McDermott M, Munoz D, Nassiri F, Noushmehr H, Ng HK, Perry A, Pirouzmand F, Poisson LM, Pollo B, Raleigh D, Sahm F, Saladino A, Santarius T, Schichor C, Schultz D, Schmidt NO, Selman W, Sloan A, Spears J, Snyder J, Suppiah S, Tabatabai G, Tatagiba M, Tirapelli D, Tonn JC, Tsang D, Vogelbaum MA, von Deimling A, Wen PY, Walbert T, Westphal M, Workewych AM, Zadeh G
Journal nameNeuro-Oncology
Year2019
Month1
Day14
Volume Number21
Issue NumberSupplement_1
PublisherOxford University Press (OUP): Policy B - Oxford Open Option F
Pagesi18 - i31
ISSN1522-8517
LanguagesEnglish-United Kingdom
Keywordsclinical trial, meningioma, radiation, surgery, targeted therapy
Web of Science Subject CategoriesOncology;Clinical Neurology;Oncology;Neurosciences & Neurology

Last updated on 2020-01-04 at 02:29