Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要In epigenome-wide association studies, the measured signals for each sample are a mixture of methylation profiles from different cell types. Current approaches to the association detection claim whether a cytosine-phosphate-guanine (CpG) site is associated with the phenotype or not at aggregate level and can suffer from low statistical power. Here, we propose a statistical method, HIgh REsolution (HIRE), which not only improves the power of association detection at aggregate level as compared to the existing methods but also enables the detection of risk-CpG sites for individual cell types.
著者LUO Xiangyu, YANG Can, WEI Yingying
期刊名稱Nature Communications
出版年份2019
月份7
日期15
卷號10
出版社Nature Research (part of Springer Nature): Fully open access journals / Nature Publishing Group
文章號碼3133
國際標準期刊號2041-1723
語言英式英語

上次更新時間 2021-27-02 於 02:12