Prognostic significance of interferon regulating factor 4 in esophageal squamous cell carcinoma
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摘要Background: Aberrant expression of interferon regulatory factor 4 (IRF4) has been reported in several hematologic malignancies. However, the prognostic significance of IRF4 expression in esophageal squamous cell carcinoma (ESCC) remains unknown.

Methods: IRF4 protein expression in ESCC tumor specimens was determined immunohistochemically. The correlation of IRF4 expression with clinico-pathological features was assessed from a cohort of 100 patients with primary ESCC. Kaplan-Meier and Cox proportional regression analyses were used to evaluate the association between IRF4 expression and patient survival.

Results: A Kaplan-Meier analysis indicated that patients with high IRF4 expression had a significantly longer overall survival rate than those with low IRF4 expression (p = 0.0006). Furthermore, multi-variate analyses revealed that IRF4 protein expression is an independent prognostic indicator for ESCC patients.

Conclusion: Our results suggest that increased IRF4 protein expression correlates with improved outcome in ESCC. IRF4 may therefore represent a promising prognostic biomarker and potential immuno-therapeutic target for patients with ESCC.
著者Sun, Ye, Zhang, Qiu, Xiang, Tang, Wang, Li, Luo, Zhang, Ren
期刊名稱Biochemical and Biophysical Research Communications
出版年份2018
月份11
日期30
卷號506
期次3
出版社Elsevier
頁次685 - 691
國際標準期刊號0006-291X
語言英式英語

上次更新時間 2020-23-11 於 01:57