Central obesity is associated with low bone mineral density at femoral neck in Chinese men living with HIV
Refereed conference paper presented and published in conference proceedings


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摘要Objectives
This study aims to determine whether metabolic syndrome and its components are associated with low bone mineral density (BMD) in HIV-infected individuals.
Methods
A prospective study was performed. BMD at femoral neck and lumbar spine were measured by DEXA. Metabolic syndrome was defined as the presence of any three of the following: central obesity, triglycerides>1.7mmol/L, reduced HDL-cholesterol, blood pressure≥130/85mmHg, and fasting plasma glucose≥5.6mmol/L. Low BMD was defined as T score <-1.0 in men ≥50years and post-menopausal women, and Z score <-2.0 in those younger than 50. Multivariable logistic regression models were performed to determine independent predictors of low BMD.
Results
One hundred and eighty-eight subjects were recruited: 157 (83.5%) male, mean±SD age 53.2±13.1years, and 176(93.6%) Chinese. HIV duration was 10(IQR 4-15) years, current CD4 count was 529±282cells/mm3, 80.7% had HIV viral load <50copies/mL.
Metabolic syndrome was present in 89(47.3%) subjects, with 74(39.4%) having central obesity, 85(45.7%) elevated triglyceride, 85(45.7%) low HDL cholesterol, 119(63.3%) high blood pressure, and 95(50.8%) impaired fasting glucose/diabetes. A total of 65(34.6%) subjects had low BMD at femoral neck (30.6% in men, 54.8% in women), while 50(26.7%) had low BMD at lumbar spine (22.4% in men, 48.4% in women).
On univariate analysis, low BMD at femoral neck was associated with metabolic syndrome, central obesity, elevated triglyceride, high blood pressure, and impaired fasting glucose/diabetes in men. No association between metabolic syndrome and BMD was identified in women. Using a multivariable logistic regression model, central obesity (adjusted odds ratio/aOR 4.14, 95%CI 1.27-13.51), age (aOR 1.05, 95%CI 1.01-1.10), and body weight (aOR 0.92, 95%CI 0.87-0.97) significantly correlated with low BMD at femoral neck in men, after adjusting for confounding factors (Table). No correlation was detected between metabolic syndrome and BMD at lumbar spine in both men and women.
Conclusion
Central obesity was associated with low BMD at femoral neck in Chinese men living with HIV.
著者Lui G, Wong CK, Lee N, Cheung CS, Wong RYK, Chan WL, Kwok TCY
會議名稱20th International Workshop on Co-morbidities and Adverse Drug Reactions in HIV
會議開始日13.10.2018
會議完結日14.10.2018
會議地點New York
會議國家/地區美國
會議論文集題名Antiviral Therapy
出版年份2018
卷號23
期次Suppl 1
文章號碼A43
國際標準期刊號1359-6535
電子國際標準期刊號2040-2058
語言美式英語

上次更新時間 2019-24-10 於 15:06