Magnolol, Honokiol and Their Combination Attenuate the Cognitive Impairments Induced by Beta Amyloid1-42 in Rats via PI3K/AKT/GSK-3β Signaling Pathway
Refereed conference paper presented and published in conference proceedings


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摘要Alzheimer’s disease (AD) is the most common form of dementia in elderly people with huge healthcare and economic burden to the society. Magnolol and honokiol are two ligands isolated from Magnolia officinalis, and can cross the blood-brain barrier. Magnolol and honokiol have been found to improve the memory and learning deficits found in SAMP8 mice. Recent study in our laboratory indicated that honokiol could prevent the learning and memory impairments induced by scopolamine in mice. The aim of this study was to compare the cognitive deficits improving effects of magnolol, honokiol and their combination in Aβ1-42-treated rats. After drugs treatment for 21 days, the spatial learning and memory functions were assessed using Morris water maze test. Our results showed that magnolol, honokiol or their combination could significantly improve the spatial learning and memory functions in Aβ1-42-treated rats. Mechanistically, magnolol, honokiol or their combination markedly decrease the protein levels of Aβ1-40 and Aβ1-42 in the hippocampus of Aβ1-42-treated rats. In addition, magnolol, honokiol or their combination could significantly suppress the Aβ accumulation via enhancement of the α-secretase activity and inhibition of the β-secretase activity (BACE-1). Moreover, magnolol, honokiol or their combination could markedly inhibit the neuro-inflammation induced by Aβ1-42 in the hippocampus of rats and the protein levels of p-GSK-3β (Ser9), while increase the protein level of p-Akt (Ser473) in the hippocampus of Aβ1-42-treated rats. Our results demonstrate that the combination of magnolol and honokiol could ameliorate the learning and memory impairments in Aβ1-42-treated rats, indicating that they are promising natural compounds for further development into anti-AD therapeutics.

Acknowledgement: This work was funded by a CUHK Direct Grant (project no. 2017.076).
著者Yan-Fang Xian, Siu-Po Ip, Hui-Qin Li, Zhi-Xiu Lin
會議名稱International Conference on Brain Research in Chinese Medicine: Degeneration and Repair
會議開始日26.07.2018
會議完結日28.07.2018
會議地點Hong Kong
會議國家/地區香港
會議論文集題名International Conference on Brain Research in Chinese Medicine: Degeneration and Repair
出版年份2018
月份7
語言英式英語

上次更新時間 2019-27-11 於 09:21