Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要The data for oligoclonal IgG bands (OCB) in cerebrospinal fluid and the association with clinical profiles of Chinese patients with multiple sclerosis (MS) is lacking. We aimed to investigate the positive OCB incidence, as well as the clinical and magnetic resonance imaging (MRI) features associated with positive OCB in MS patients in South China. Consecutive MS patients were recruited from two centers, located in Guangzhou city and Hong Kong in South China. MS was re-diagnosed by McDonald criteria 2017. OCB was tested using isoelectric focusing method. The difference in the clinical and MRI features between OCB-positive and OCB-negative MS patients was evaluated. Among 184 MS patients analyzed (102 from Guangzhou and 82 from Hong Kong), 110 (59.8%) patients were OCB-positive. Except for onset age (P= 0.019), there was no significant difference between MS patients with or without OCB in relation to the course of disease, symptoms of first attack, lesion distribution on MRI, relapse rates, or disability progression. Our results demonstrate no significant clinical differences between the OCB positive and negative MS patients in this MS cohort. Larger cohort in Chinese patients with MS is warranted. (C) 2019 Elsevier Ltd. All rights reserved.
出版社接受日期21.05.2019
著者Lu, Zhao, Sun, Au, Huang, Yang, Bao, Wu, Kermode, Qiu, Lau
期刊名稱Journal of Clinical Neuroscience
出版年份2019
月份8
卷號66
出版社Elsevier
頁次51 - 55
國際標準期刊號0967-5868
語言英式英語

上次更新時間 2021-02-05 於 00:18