Comparison of Three Left Atrial Appendage Occlusion Devices for Stroke Prevention in Patients With Non-valvular Atrial Fibrillation: a Single-centre Seven-year Experience With Watchman, Amplatzer Cardiac Plug/Amulet, Lambre
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AbstractAims: We aimed to compare long-term “real-world” outcomes of three left atrial appendage occlusion (LAAO) devices for stroke prevention in a Chinese population with non-valvular atrial fibrillation (NVAF).

Methods and results: Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-affiliated hospital were retrospectively analysed. In-hospital and major adverse events (MAE) including mortality, stroke and major bleeding rates were compared by LAAO device. One hundred and sixty-one (161) patients (mean age 71.4±8.2 years; 67.7% male) with mean CHA2DS2-VASc score of 4.1±1.6 and HAS-BLED score of 2.9±1.1 underwent 162 LAAO procedures, of which 47.5% (n=77), 41.4% (n=67) and 11.1% (n=18) were AMPLATZER Cardiac Plug (ACP)/Amulet, WATCHMAN and LAmbre, respectively. The procedural success rate was 97.5% (158/162). The in-hospital adverse event rate was 7.4% (12/162) and comparable among devices (p=NS). Mean follow-up duration was 28.3±24.4 months (373 patient-years). There were no significant differences in long-term MAE rates among devices (p=NS). Observed annual ischaemic stroke (1.1% vs. 5.1%, p<0.001) and major bleeding rates (2.7% vs. 4.5%, p=NS) were lower compared with the predicted rates, respectively.

Conclusions: The WATCHMAN, ACP/Amulet and LAmbre LAAO devices demonstrated similar longterm safety and efficacy in prevention of ischaemic stroke and major bleeding in patients with NVAF.
All Author(s) ListGary SH. Cheung, Kent CY. So, Christy KY. Chan, Anna KY. Chan, Alex PW. Lee, Yat-yin Lam, Bryan P. Yan
Journal nameAsiaIntervention
Volume Number5
Pages57 - 63
LanguagesEnglish-United Kingdom

Last updated on 2020-06-08 at 04:33