Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要Gastric cancer (GC) is one of the most wide-spread malignancies in the world. The oncogenic role of signaling of fibroblast growing factors (FGFs) and their receptors (FGFRs) in gastric tumorigenesis has been gradually elucidated by recent studies. The expression pattern and clinical correlations of FGF and FGFR family members have been comprehensively delineated. Among them, FGF18 and FGFR2 demonstrate the most prominent driving role in gastric tumorigenesis with gene amplification or somatic mutations and serve as prognostic biomarkers. FGF-FGFR promotes tumor progression by crosstalking with multiple oncogenic pathways and this provides a rational therapeutic strategy by co-targeting the crosstalks to achieve synergistic effects. In this review, we comprehensively summarize the pathogenic mechanisms of FGF-FGFR signaling in gastric adenocarcinoma together with the current targeted strategies in aberrant FGF-FGFR activated GC cases.
著者Zhang J, Tang PMK, Zhou Y, Cheng ASL, Yu J, Kang W, To KF
期刊名稱Cells
出版年份2019
月份6
日期25
卷號8
期次6
出版社MDPI
文章號碼637
國際標準期刊號2073-4409
語言英式英語

上次更新時間 2020-15-08 於 04:02