Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
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AbstractGastric cancer (GC) is one of the most wide-spread malignancies in the world. The oncogenic role of signaling of fibroblast growing factors (FGFs) and their receptors (FGFRs) in gastric tumorigenesis has been gradually elucidated by recent studies. The expression pattern and clinical correlations of FGF and FGFR family members have been comprehensively delineated. Among them, FGF18 and FGFR2 demonstrate the most prominent driving role in gastric tumorigenesis with gene amplification or somatic mutations and serve as prognostic biomarkers. FGF-FGFR promotes tumor progression by crosstalking with multiple oncogenic pathways and this provides a rational therapeutic strategy by co-targeting the crosstalks to achieve synergistic effects. In this review, we comprehensively summarize the pathogenic mechanisms of FGF-FGFR signaling in gastric adenocarcinoma together with the current targeted strategies in aberrant FGF-FGFR activated GC cases.
All Author(s) ListZhang J, Tang PMK, Zhou Y, Cheng ASL, Yu J, Kang W, To KF
Journal nameCells
Year2019
Month6
Day25
Volume Number8
Issue Number6
PublisherMDPI
Article number637
ISSN2073-4409
LanguagesEnglish-United Kingdom

Last updated on 2020-05-04 at 01:20