A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要(+/-)-Cryptomeriolide, a pair of racemic bis-seco-abietane diterpenoids, were isolated from the bark of Cryptomeria fortunei. The separation of enantiomers was achieved by using chiral stationary phase HPLC. Their structures including the absolute configuration and conformations in solution and solid state were determined by extensive analysis of spectroscopic data, single-crystal X-ray diffraction, and comparison of calculated and experimental electronic circular dichroism data. A bioinspired one-pot enantiomeric synthesis of 1a and 1b was accomplished via a readily made intermediate orthoquinone from sugiol. All compounds including the synthetic intermediates were assayed for their cytotoxic activities on human cancer cell lines HL-60, A549, and SGC7901.
著者FENG Lu, MANDI Attila, TANG Chunping, KURTAN Tibor, TANG Shuai, KE Chang-Qiang, SHEN Ning, LIN Ge, YAO Sheng, YE Yang
期刊名稱Journal of Natural Products
出版年份2018
月份12
卷號81
期次12
出版社AMER CHEMICAL SOC
頁次2667 - 2672
國際標準期刊號0163-3864
電子國際標準期刊號1520-6025
語言英式英語
Web of Science 學科類別Plant Sciences;Chemistry, Medicinal;Pharmacology & Pharmacy;Plant Sciences;Pharmacology & Pharmacy

上次更新時間 2021-21-09 於 00:06