Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Ten new sesquiterpene lactones, carlipsines A J (1-10), and 12 known analogues (11-22) were isolated from the whole plant of Carpesium lipskyi. Their structures were elucidated by using 1D and 2D NMR and HRESIMS analyses, and their absolute configurations were confirmed by X-ray diffraction studies. All compounds were identified as germacranolides with diverse substructural features. Compounds 1-4 are 2,5-hemiacetal-linked germacranolides. Compounds 5 and 6 possess a 1,2-epoxy moiety. Compounds 7 and 8 represent unusual 1,5-hemiacetal-linked germacranolides. Compounds 9 and 10 contain a tetrahydrofuran unit with the oxygen atom bridging C-1 and C-8. Compounds 6, 7, 8, 19, 20, 21, and 22 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.8 to 10.3 mu M.
著者Nan-Lin ZHU, Chunping TANG, Chenghui XU, Chang-Qiang KE, Ge LIN, Janar JENIS, Sheng YAO, Hongchun LIU, Yang YE
期刊名稱Journal of Natural Products
出版年份2019
月份3
日期14
卷號82
期次4
出版社AMER CHEMICAL SOC
頁次919 - 927
國際標準期刊號0163-3864
電子國際標準期刊號1520-6025
語言英式英語

上次更新時間 2021-19-09 於 00:02