Endocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Research question
To evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome (MS) in women with polycystic ovary syndrome (PCOS), and whether these associations are modified by body mass index (BMI).
Design
Secondary analysis of baseline data from a randomized controlled trial of PCOS for ovulation induction.
Result(s)
Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with MS. The prevalence of MS in women with normal (<24) and high (≥24) BMI was 3.6% and 30.5%, respectively. In all women, high free androgen index (FAI≥5%) was positively associated with MS (OR 2.06, 95%CI 1.11-3.82). High FAI was positively associated with MS among women with high BMI (OR 3.37, 95%CI 1.78-6.37), but the association was not significant in women with normal BMI (OR 1.27, 95%CI 0.34-4.70). The presence of polycystic ovary (PCO) morphology was negatively associated with MS (OR 0.52, 95%CI 0.26-1.03) in all women (normal BMI OR 0.42, 95%CI 0.11-1.67; high BMI OR 0.54, 95%CI 0.23-1.28, respectively). Luteinizing hormone (LH), Sex hormone binding globulin (SHBG), and anti-mullerian hormone (AMH) were negatively associated with MS. The associations of FAI, SHBG, and AMH in relation to MS were significantly modified by BMI.
Conclusion(s)
The associations of endocrine characteristic with MS were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of MS.
出版社接受日期28.06.2019
著者Li Jian, Wu Qi, Wang Chi Chiu, Wang Rui, Ng Ernest H.Y., Liu Jian-Ping, Mol Ben Willem. J., Wu Xiao-Ke, Li Wentao, PCOSAct Study Group
期刊名稱Reproductive BioMedicine Online
出版年份2019
月份11
卷號39
期次5
出版社Elsevier
頁次868 - 876
國際標準期刊號1472-6483
電子國際標準期刊號1472-6491
語言英式英語
關鍵詞Polycystic ovary syndrome, metabolic syndrome, body mass index

上次更新時間 2021-23-02 於 01:25