Bone Mass, Microstructure, and Strength Can Discriminate Vertebral Fracture in Patients on Long-Term Steroid Treatment
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AbstractContext
Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) was able to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric bone mineral density (vBMD), microarchitecture, and strength that may increase our understanding of fracture susceptibility.

Objective
To ascertain whether vBMD, microarchitecture, and estimated bone strength derived from HR-pQCT can discriminate vertebral fractures in patients with glucocorticoid-induced osteoporosis (GIOP) independent of aBMD.

Design
A cross-sectional case-control study.

Setting
Seven regional hospitals in Hong Kong.

Patients
A total of 110 patients on long-term glucocorticoids with vertebral fracture, determined radiographically, and 110 patients on long-term glucocorticoids without fracture.

Main Outcome Measures
We assessed vBMD, microarchitecture, and bone strength; aBMD; and fracture risk assessment tool (FRAX).

Results
Patients with vertebral fracture had lower total vBMD and a thinner cortex at the distal tibia after adjustment for age, sex, and aBMD or FRAX. In the antiresorptive treatment–naive subgroup, patients with vertebral fracture also had lower total vBMD at both the distal radius and the tibia after adjustment for covariates. Lower total vBMD and a thinner cortex were also noticed in the nonosteoporotic or FRAX score of <10% subgroups with vertebral fracture and were also associated with increasing prevalence of vertebral fracture.

Conclusion
Patients with GIOP and vertebral fracture have a significant reduction in total vBMD and cortical thinning independent of aBMD and FRAX. These changes may help identify high-risk patients in the subgroups currently considered to have low fracture risk as assessed by DXA or FRAX.
Acceptance Date02/07/2018
All Author(s) ListJiayun Shen, James F Griffith, Tracy Y Zhu, Peggy Tang, Emily W Kun, Violet K Lee, Ronald M Yip, Kitty Y Kwok, Shirley K Ying, Carmen T Ho, Sze-Lok Lau, Michelle O Pui, Tena K Li, Eleven Y Lau, Jack J Lee, Ling Qin, Lai-Shan Tam
Journal nameJournal of Clinical Endocrinology and Metabolism
Year2018
Month9
Volume Number103
Issue Number9
PublisherOxford University Press
Pages3340 - 3349
ISSN0021-972X
eISSN1945-7197
LanguagesEnglish-United Kingdom

Last updated on 2020-20-11 at 03:06