Hepatitis B surface antigen seroclearance in a cohort of 154,740 patients with chronic hepatitis B: a 15-year follow-up study
Refereed conference paper presented and published in conference proceedings


摘要Background: Cohort studies suggest hepatitis B surface antigen (HBsAg) seroclearance before 50 years old and development of cirrhosis is associated with minimal risk of hepatocellular carcinoma (HCC). The probability of HBsAg seroclearance of a large real-life cohort of patients who lost HBsAg was evaluated.

Methods: Consecutive Chinese patients with chronic hepatitis B (CHB) retrieved from the Clinical Data Analysis and Reporting System (CDARS) from Hospital Authority (HA) from January 2000 to August 2016 were studied. Serial HBsAg results were retrieved and the cumulative probability of HBsAg seroclearance was estimated.

Result: 154,740 patients who had at least one positive HBsAg result were identified. Among them 6919 patients (4.47%) lost HBsAg during a median (interquartile range) follow-up period of 45 (12–83) months. 239 out of 6919 patients (3.45%) subsequently had HBsAg reversion at a median of 20 (9–48) months after HBsAg seroclearance. The cumulative probabilities of HBsAg seroconversion in 1, 3, 5, and 10 years were 2.9, 4.9, 7.6, and 18.1% respectively. On the other hand, the cumulative probabilities of HBsAg seroconversion at 40, 50, 60, and 70 years of age were 2.2, 4.5, 9.6, and 17.2% respectively. Patients who lost HBsAg were older and more likely to
be male.

Conclusion: HBsAg seroclearance occurs uncommonly among Chinese CHB patients but slowly increases with age, with a cumulative probability of 17.2% at 70 years of age. HBsAg reversion was rare after HBsAg seroclearance. Future studies show focus on the impact of HBsAg seroclearance on clinical outcome.
著者Terry Cheuk-Fung Yip, Vincent Wai-Sun Wong, Yee-Kit Tse, Henry Lik-Yuen Chan, Grace Lai-Hung Wong
會議名稱The 26th Annual Conference of Asian Pacific Association for the Study of the Liver (APASL)
會議論文集題名Hepatology International
期次Suppl 1
頁次S75 - S76

上次更新時間 2019-21-10 於 16:16