Increasing prevalence of indications to choose bone/renal-friendly antiviral drug: A territory-wide study of 135, 414 patients from 2000 to 2017
Refereed conference paper presented and published in conference proceedings


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摘要Background and aims: The latest clinical practice guideline from European Association for the Study of the Liver (EASL) published in 2017 advocate the use of entecavir or tenofovir alafenamide (TAF) over tenofovir disoproxil fumarate (TDF) according to age, bone disease and renal alteration. As patients with chronic hepatitis B (CHB) are aging with improved survival under better healthcare, more patients may fulfil these criteria. We aimed to determine the prevalence of these criteria in the territory-wide CHB cohort in Hong Kong over 18 years from year 2000 to 2017.

Method: CHB patients who have been under the care at primary, secondary and tertiary medical centers in the public sector in Hong Kong were identified through the Clinical Data Analysis and Reporting System of the Hospital Authority. The demographics and prevalence of relevant bone and renal co-morbidities, and relevant laboratory parameters were determined according to patients’ first appearance in four time periods: 2000-2004, 2005-2009, 2010-2013 and 2014-2017.

Results: 136, 414 CHB patients were included. The prevalence of the above criteria increased over the four periods: age >60 years 11.6%, 20.4%, 27.6% and 35.4%; Steroid/medications that worsen bone density 57.2%, 50.5%, 56.0% and 61.8% respectively; albuminuria 0.2% 0.4% 0.7% and 1.1% respectively, and low phosphate (<2.5 mg/dl) 3.9%, 4.0%, 5.1% and 7.0% respectively (all P < 0.001; Figure).

Conclusion: CHB patients are getting older with increasing prevalence of indications to choose entecavir or TAF over TDF according to the latest EASL guidelines.

Funding: This work was supported by the Investigator Sponsored Research of Gilead Sciences (Reference: IN-US-988-5290).
著者Grace Lai-Hung Wong, Becky Wing-Yan Yuen, Yee-Kit Tse, Hester Wing-Sum Luk, Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
會議名稱European Association for the Study of the Liver (EASL) The International Liver Congress™ 2019
會議開始日10.04.2019
會議完結日14.04.2019
會議地點Vienna
會議國家/地區奧地利
會議論文集題名Journal of Hepatology
出版作品名稱JOURNAL OF HEPATOLOGY
出版年份2019
月份4
卷號70
期次Suppl 1
出版社ELSEVIER SCIENCE BV
頁次E269 - E269
國際標準期刊號0168-8278
語言英式英語
Web of Science 學科類別Gastroenterology & Hepatology;Gastroenterology & Hepatology

上次更新時間 2020-05-08 於 06:01