Increasing prevalence of indications to choose bone/renal-friendly antiviral drug: A territory-wide study of 135, 414 patients from 2000 to 2017
Refereed conference paper presented and published in conference proceedings


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AbstractBackground and aims: The latest clinical practice guideline from European Association for the Study of the Liver (EASL) published in 2017 advocate the use of entecavir or tenofovir alafenamide (TAF) over tenofovir disoproxil fumarate (TDF) according to age, bone disease and renal alteration. As patients with chronic hepatitis B (CHB) are aging with improved survival under better healthcare, more patients may fulfil these criteria. We aimed to determine the prevalence of these criteria in the territory-wide CHB cohort in Hong Kong over 18 years from year 2000 to 2017.

Method: CHB patients who have been under the care at primary, secondary and tertiary medical centers in the public sector in Hong Kong were identified through the Clinical Data Analysis and Reporting System of the Hospital Authority. The demographics and prevalence of relevant bone and renal co-morbidities, and relevant laboratory parameters were determined according to patients’ first appearance in four time periods: 2000-2004, 2005-2009, 2010-2013 and 2014-2017.

Results: 136, 414 CHB patients were included. The prevalence of the above criteria increased over the four periods: age >60 years 11.6%, 20.4%, 27.6% and 35.4%; Steroid/medications that worsen bone density 57.2%, 50.5%, 56.0% and 61.8% respectively; albuminuria 0.2% 0.4% 0.7% and 1.1% respectively, and low phosphate (<2.5 mg/dl) 3.9%, 4.0%, 5.1% and 7.0% respectively (all P < 0.001; Figure).

Conclusion: CHB patients are getting older with increasing prevalence of indications to choose entecavir or TAF over TDF according to the latest EASL guidelines.

Funding: This work was supported by the Investigator Sponsored Research of Gilead Sciences (Reference: IN-US-988-5290).
All Author(s) ListGrace Lai-Hung Wong, Becky Wing-Yan Yuen, Yee-Kit Tse, Hester Wing-Sum Luk, Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
Name of ConferenceEuropean Association for the Study of the Liver (EASL) The International Liver Congress™ 2019
Start Date of Conference10/04/2019
End Date of Conference14/04/2019
Place of ConferenceVienna
Country/Region of ConferenceAustria
Proceedings TitleJournal of Hepatology
Title of PublicationJOURNAL OF HEPATOLOGY
Year2019
Month4
Volume Number70
Issue NumberSuppl 1
PublisherELSEVIER SCIENCE BV
PagesE269 - E269
ISSN0168-8278
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGastroenterology & Hepatology;Gastroenterology & Hepatology

Last updated on 2021-25-06 at 00:21