Maternal β-HCG concentrations in early IVF pregnancy: association with the embryo development stage of blastocysts
Publication in refereed journal

替代計量分析
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其它資訊
摘要Research question
Does the blastocyst development stage on embryo transfer day affect serum β-human chorionic gonadotrophin (β-HCG) concentration 9 and 16 days after embryo transfer in women whose pregnancy progresses beyond 13 weeks?

Design
Retrospective study involving 204 cases where pregnancy progressed beyond 13 weeks of single blastocyst transfer in fresh (n = 66) or frozen embryo transfer (FET) (n = 138) cycles from January 2015 to September 2016.

Results
β-HCG concentrations 9 and 16 days after embryo transfer in FET cycles (median 223 IU/l and 4378 IU/l, respectively) were significantly (P < 0.001) higher than in fresh cycles (157 IU/l and 2813 IU/l). Among fresh cycles, faster-growing blastocysts (expanded + hatching + hatched blastocysts) produced significantly (P < 0.001) higher β-HCG concentrations 9 days after embryo transfer (191 IU/l) than slower-growing blastocysts (cavitating + full blastocyst, 106 IU/l); however no significant difference was found between the faster- and slower-growing groups by day 16 (2359 IU/l and 3025 IU/l, respectively). Among FET cycles, there was no difference in β-HCG concentration between blastocysts of different development stages 9 and 16 days after transfer.

Conclusions
Faster-growing blastocysts produced significantly higher serum β-HCG concentrations 9 days after transfer than slower-growing blastocysts in fresh cycles, but the difference was not significant by day 16 after transfer. Also, β-HCG concentrations 9 and 16 days after embryo transfer in FET cycles were higher than in fresh embryo transfer cycles. Interpretation of β-HCG results 9 days after blastocyst transfer should consider the blastocyst growth rate and whether fresh or cryopreserved embryo was transferred.
出版社接受日期19.11.2018
著者Zhu Wenyue, Yeung Queenie, Chan David, Chi Ling, Huang Jin, Wang Qiong, Chung Jacqueline, Li Tin Chiu
期刊名稱Reproductive BioMedicine Online
出版年份2019
月份5
卷號38
期次5
出版社Elsevier
頁次683 - 690
國際標準期刊號1472-6483
電子國際標準期刊號1472-6491
語言英式英語
關鍵詞Blastocyst development stage, Early pregnancy, Implantation, IVF, β-human chorionic gonadotrophin

上次更新時間 2021-07-05 於 01:15