Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
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摘要Background: While the importance of identifying osteoporotic vertebral endplate fracture (EPF) is being recognized; the pathophysiological understanding of EPF till now remain insufficient. In this population-based cross-sectional radiograph study, we aim to investigate the anatomic location characteristics of osteoporotic EPF.Methods: This study analyzed the anatomical location of osteoporotic EPFs in elderly Chinese population (age >= 65 years). The T4-L4 radiographs of 1,954 elderly Chinese men (mean: 72.3 years) and 1,953 elderly Chinese women (mean: 72.5 years) were evaluated to identify EPF, and vertebral bodies were graded according to Genant's vertebral deformity criteria.Results: Of the 101,582 endplates analyzed, there were 505 EPFs (males: 27.7%; females: 72.3%). Excluding those with both upper endplate and lower endplate involvements, the ratio of upper EPF to lower EPF was 9.63 for males and 4.3 for females (P<0.05). Thoracolumbar junction, particularly LI (26.4% for males and 24.1% for females) and followed by T12 (20.7% for males and 19.7% for females), had highest prevalence of EPF. With an endplate divided into 5 segments of equal length in the anteroposterior direction and grade 0.5 & 1, grade 2 vertebral deformities analyzed, fractures occurred mostly at the middle segment (70.1% for upper endplates in males and 78.6% for upper endplates in females), followed by second anterior segment (20.9% for upper endplates in males and 14.4% for upper endplates in females). The most anterior and most posterior segments were not primarily involved in EPF.Conclusions: Osteoporotic EPFs more likely involve the upper endplate rather than lower endplate, with a trend for this effect to be greater in men than in women. These characteristics may help radiographic differential diagnosis for osteoporotic EPF.
著者Che-Nordin N, Deng M, Griffith JF, Leung JCS, Kwok AWL, Zhu YQ, So RHY, Kwok TCY, Leung PC, Wáng YXJ
期刊名稱ANNALS OF TRANSLATIONAL MEDICINE
出版年份2018
月份11
卷號6
期次22
出版社AME PUBL CO
文章號碼442
國際標準期刊號2305-5839
電子國際標準期刊號2305-5847
語言英式英語
關鍵詞Epidemiology, radiograph, osteoporosis, osteoporotic fractures, endplate
Web of Science 學科類別Oncology;Medicine, Research & Experimental;Oncology;Research & Experimental Medicine

上次更新時間 2021-12-09 於 00:47