Bone measurements at multiple skeletal sites in adolescent idiopathic scoliosis—an in vivo correlation study using DXA, HR-pQCT and QCT
Publication in refereed journal


Significant correlations for bone mineral density and bone microstructure between spinal and non-spinal skeletal sites (distal radius and proximal femur) in adolescent idiopathic scoliosis (AIS) patients were observed, indicating that proximal femoral DXA and distal radial HR-pQCT could provide valid clinical assessments in patients with AIS.

Low bone mass is an important feature of adolescent idiopathic scoliosis (AIS), which is a complex 3D spinal deformity that affects girls during puberty. However, no clinical imaging modality is suitable for regular monitoring on their spinal bone qualities in rapid growth period. Therefore, we investigated whether bone mineral density (BMD) and bone microstructure at non-spinal sites correlated with BMD and mechanical property in the spine in AIS patients.

Thirty-two AIS girls (16.7 ± 3.5 years old with mean Cobb angle of 67 ± 11°) who underwent pre-operative spine CT examination for navigation surgery were recruited. Volumetric BMD (vBMD) of lumbar spine (LS) was measured by quantitative computed tomography (QCT), vBMD and bone microstructure of distal radius (DR) by high-resolution peripheral QCT (HR-pQCT) and areal BMDs of total hip (TH) and femoral necks (FN) by dual-energy X-ray absorptiometry (DXA). Biomechanical properties of the DR and LS were estimated by finite element analysis (FEA). Pearson correlation was performed to study the correlation between bone parameters at these three sites.

LS vBMD correlated significantly with both FN and TH aBMD (R = 0.663–0.725, both p < 0.01) and with DR microstructural parameters (R = 0.380–0.576, all p < 0.05). Mechanical properties of LS and DR were also correlated (R = 0.398, p = 0.039).

Bone measurement at proximal femur and distal radius could provide an additional predictive power in estimating the bone changes at spine, which is the primary site of deformity in AIS patients. Our result indicated that DXA and HR-pQCT could provide a valid surrogate for spine bone measurements in AIS patients.
著者Ka Yee Cheuk, Yizhong Hu, Elisa M. S. Tam, Lin Shi, Fiona W. P. Yu, Vivian W. Y. Hung, Kevin Cheuk Yin Lai, Wilson Ho Wu Cheng, Benjamin H. K. Yip, Ling Qin, Bobby K. W. Ng, Winnie C. W. Chu, James Griffith, X. Edward Guo, Jack C. Y. Cheng, Tsz Ping Lam
期刊名稱Archives of Osteoporosis
詳細描述Ka Yee Cheuk and Yizhong Hu contributed equally to this work.
關鍵詞Adolescent idiopathic scoliosis, Bone mechanical property, Bone microstructure, Finite element analysis, Quantitative computed tomography, Spine

上次更新時間 2021-17-06 於 00:32