Personal Exposure to PM2.5 and Its Bioreactivity in Healthy Adults of Hong Kong
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AbstractBackground: Mechanisms involving systemic in��ammation have been proposed to explain the associations between PM with cardiopulmonary morbidity and mortality. Experimental evidence suggests that organic constituents in PM have critical health impact. However, there are limited studies related to the bioreactivity of personal PM in vitro with toxic components. Methods: Personal monitoring from 58 (aged 18-42 years) healthy adults during the summer and winter were conducted in Hong Kong. Personal exposures to PM as well as its chemical components including organic carbon, elemental carbon, polycyclic aromatic hydrocarbons (PAHs), and phthalates in personal samples were determined. Additionally, the bioreactivity of personal PM invitro were evaluated. Cell variability, 8-isoprostane, lactate dehydrogenase (LDH), and interleukin-6 (IL-6) released were used to determined the PM bioreactiviy. Using the mixed-e��ects model, the relationships of bioreactivity to personal exposure to PM components were examined. Results: Winter exposures were 1.6-2.0 times greater than summer exposures for personal PM , EC, PAHs, and phthalate. Personal exposure to OC was signi��cantly correlated with LDH (p < 0.05) and IL-6 (p < 0.01). Moderate correlations (r = 0.58, p < 0.05) were observed between OC and EC, but no correlations were observed between EC with bioreactivity of PM . Conclusion: In vitro methods have an important role in the screening of bioreactivity of PM . Results suggest exposure to PM components can induce cytotoxicity and system in��ammation in healthy adults.
Acceptance Date26/08/2018
All Author(s) ListChen Xiao-Cui, Hsiao-Chi Chuang, Ngar-Cheung Lau, Hung-Lam Yim, Kin-Fai Ho
Name of ConferenceISES-ISEE 2018 Joint Annual Meeting
Start Date of Conference26/08/2018
End Date of Conference30/08/2018
Place of ConferenceOttawa
Country/Region of ConferenceCanada
LanguagesEnglish-United States

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