Traditional Chinese Medicine in Pediatric Oncology: A Systematic Review of Clinical Studies Published in the Chinese Literature
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: The use of traditional and complementary medicine in oncology has become increasingly prevalent. In Asian countries like China, Traditional Chinese Medicine (TCM) is commonly used as a supportive treatment though its clinical evidence is scarce. Based on the existing Chinese literature, this systematic review summarizes clinical studies of TCM use in pediatric oncology.

Methods: A systematic search was conducted in six major Chinese biomedical databases for clinical studies (published before December 2018) of TCM therapies in pediatric patients (≤18 years) with cancer. Methodological quality of studies was assessed using the Jadad Scale.

Results: Forty-three reports were included, comprising randomized controlled trials (n=23, 53.5%) and controlled clinical studies (n=27, 62.8%). Studies focused on children with leukemia (60.5%), neuroblastoma (11.6%), and heterogenous cancer diagnoses (23.3%). Methodological quality of most studies (n=31, 72.1%) was modest due to suboptimal reporting on randomization method or sample inclusion/criteria. Herbal medicine was the most common intervention, with a total of 143 herbs reported (Supplement 1). Six acupoints and two auricular acupuncture points were identified in 7 (16.3%) studies (Supplement 2). The most frequently reported endpoints were reduction in chemotherapy-induced adverse effects (n=33, 76.7%), such as nausea/vomiting and fatigue, as well as response/survival outcomes (n=17, 39.5%), and quality of life (n=9, 20.9%) (Supplement 3).

Conclusions: Preliminary evidence seems to support TCM as supportive therapy to alleviate treatment-related symptoms and improve health status in children with cancer. Reporting of clinical studies could be improved to synthesize more quality evidence and guide the use of TCM in pediatric oncology.
Acceptance Date22/03/2019
All Author(s) ListPeng Liwen, Koon Ho-Kee, Li Chi-Kong, Zuo Zhong, Cheung Yin Ting
Name of ConferenceAnnual Meeting of Multinational Association of Supportive Care in Cancer (MASCC) and the International Society of Oral Oncology (ISOO)
Start Date of Conference21/06/2019
End Date of Conference23/06/2019
Place of ConferenceSan Francisco
Country/Region of ConferenceUnited States of America
Proceedings TitleSupportive Care in Cancer: Abstracts for MASCC/ISOO Annual Meeting 2019
Year2019
Month6
Volume Number27
Issue NumberSuppl 1
PublisherSpringer
PageseP471
ISSN0941-4355
LanguagesEnglish-United States
KeywordsTraditional and complementary medicine, Traditional Chinese Medicine, Pediatric Oncology, Herbs, Acupoints

Last updated on 2020-15-01 at 16:01