THz in vivo measurements: the effects of pressure on skin reflectivity
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AbstractTerahertz (THz) light is non-ionizing and highly sensitive to subtle changes in water concentration which can be indicative of disease. The short THz penetration depth in bio-samples restricts in vivo measurements to be in a reflection geometry and the sample is often placed onto an imaging window. Upon contacting the imaging window, occlusion and compression of the skin affect the THz response. If not appropriately controlled, this could cause misleading results. In this work, we investigate and quantify how the applied pressure affects the THz response of skin and employ a stratified model to help understand the mechanisms at play. This work will enable future THz studies to have a more rigorous experimental protocol, which in turn will facilitate research in various potential biomedical applications under investigation.
Acceptance Date06/11/2018
All Author(s) ListJiarui wang, Rayko I. Stantchev, Qiushuo Sun, Tor-Wo Chiu, Anil T. Ahuja, Emma Pickwell-MacPherson
Journal nameBiomedical Optics Express
Year2018
Month12
Day1
Volume Number9
Issue Number12
PublisherOPTICAL SOC AMER
Place of PublicationWASHINGTON, DC 20036 USA
Pages6467 - 6476
ISSN2156-7085
LanguagesEnglish-United States
KeywordsBIOMEDICAL APPLICATIONS, TERAHERTZ SPECTROSCOPY

Last updated on 2020-22-11 at 02:35