Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery
Publication in refereed journal


摘要Thermosensitive hydrogels are in situ gelling systems composed of hydrophilic homopolymers or block copolymers
which remain as solutions at room temperature and form gels after administration into the body. Its
application in advanced drug delivery has gained significant attention in recent years. The tunable characteristics
of thermosensitive hydrogels make them versatile and capable of incorporating both hydrophilic and lipophilic
compounds and macromolecules. The drug molecules can be included as free molecules or preformulated
into nano- or micro-particles or liposomes. Although there were several reviews on the materials of
thermosensitive hydrogels, the compatibility between the drug and thermosensitive material as well as its in vitro
release mechanisms and in vivo performance have barely been investigated. The current review is proposed
aiming to not only provide an update on the recent development in thermosensitive hydrogel formulations for
nasal, ocular and cutaneous deliveries, but also identify the relationship between the drug characteristics and the
loading strategies, and their impacts on the release mechanisms and the in vivo performance. Our current update
for the first time highlights the essential features for successful development of in situ thermosensitive hydrogels
to facilitate nasal, ocular or cutaneous drug deliveries.
著者Qianwen Wang, Zhong Zuo, Cheuk Kit Chucky Cheung, Sharon Shui Yee Leung
期刊名稱International Journal of Pharmaceutics
頁次86 - 101
關鍵詞Thermosensitive hydrogel,In situ hydrogel,Nasal drug delivery,Ocular drug delivery,Cutaneous drug delivery,Drug characteristics,Drug release mechanisms

上次更新時間 2020-05-08 於 04:19