Screening and prevention of pre-eclampsia: a review
Publication in refereed journal


其它資訊
摘要Pre-eclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality. Early-onset PE requiring preterm delivery is associated with a higher risk of complications in both mothers and babies. It is important to identify pregnant women who are at high risk of developing PE in the first trimester, so that preventive measures can be initiated early to improve placentation and reduce the prevalence and severity of the disorder. This review illustrates that effective screening for early-onset PE can be performed in the first trimester of pregnancy by a combination of maternal risk factors, mean arterial pressure, uterine artery Doppler ultrasonography, and placental growth factor. This prediction algorithm has detection rates of 90%, 75%, and 41% for very-early (delivery <32 weeks), preterm (delivery <37 weeks), and term (delivery ≥37 weeks) PE at 10% false positive rate, respectively. This model has been validated in several populations. Recent evidence has demonstrated that administration of low-dose aspirin (150 mg/nightly) starting at 11-14 weeks of gestation to high-risk women is effective in reducing the risk of preterm PE and the length of stay in neonatal intensive care unit.
著者Chaemsaithong Piya , Appiah Eric Kubi , Sahota Daljit , Leung Tak Yeung , Poon Liona Chiu Yee
期刊名稱Hong Kong Journal of Gynaecology Obstetrics and Midwifery
出版年份2019
卷號19
期次1
出版社Hong Kong Academey of Medicine Press
頁次56 - 72
國際標準期刊號1608-9367
電子國際標準期刊號2225-904X
語言英式英語

上次更新時間 2019-11-07 於 12:28